Background

Death from stroke is linked to cancer due to its pathogenesis and side effects of treatment. Despite this, guidelines regarding identifying cancer patients at the highest risk of mortality from stroke are unclear.

Aims

To determine which cancer subtypes are associated with higher risk of death from stroke.

Methods

The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program was used to obtain data regarding patients with cancer who died of a stroke. We calculated standardized mortality ratios (SMRs) using SEER*Stat software, version 8.4.0.1.

Results

Out of 6,136,803 patients with cancer, 57,523 (0.9%) died from stroke, and this rate was higher than general population (SMR= 1.05, 95%CI [1.04-1.06]). Deaths due to stroke decreased across years, from 24,280 deaths between 2000-2004 to 4,903 deaths between 2015-2019. Of the 57,523 stroke deaths, greatest numbers were observed in cancers of the prostate (n=11,761, 20.4%), breast (n=8,946, 15.5%), colon and rectum (n=7,401, 12.8%), and lung and bronchus (n=4,376, 7.6%). Patients with colon and rectum cancers (SMR= 1.08 95%CI [1.06-1.11]), lung and bronchus cancers (SMR=1.70 95%CI [1.65-1.75]) had a greater rate of death from stroke compared to the general population.

Conclusion

The risk of death from stroke in cancer patients is significantly higher than in the general population. Patients with colorectal cancer and lung and bronchus cancer are at higher risk of death by stroke compared to the general population.

中文翻译：

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中风是癌症患者的死亡原因：一项基于 SEER 的研究

背景

由于中风的发病机制和治疗的副作用，中风死亡与癌症有关。尽管如此，关于识别因中风死亡风险最高的癌症患者的指南尚不清楚。

目标

确定哪些癌症亚型与中风死亡风险较高相关。

方法

美国国家癌症研究所的监测、流行病学和最终结果 (SEER) 计划用于获取因中风死亡的癌症患者的数据。我们使用 SEER*Stat 软件 8.4.0.1 版计算了标准化死亡率 (SMR)。

结果

在 6,136,803 名癌症患者中，57,523 名（0.9%）死于中风，这一比率高于一般人群（SMR= 1.05，95%CI [1.04-1.06]）。中风死亡人数逐年下降，从 2000 年至 2004 年期间的 24,280 人死亡人数减少到 2015 年至 2019 年期间的 4,903 人死亡人数。在 57,523 例中风死亡中，死亡人数最多的是前列腺癌（n=11,761，20.4%）、乳腺癌（n=8,946，15.5%）、结肠癌和直肠癌（n=7,401，12.8%）以及肺癌和支气管癌（n=4,376，7.6%）。与一般人群相比，结肠癌和直肠癌 (SMR= 1.08 95%CI [1.06-1.11])、肺癌和支气管癌 (SMR=1.70 95%CI [1.65-1.75]) 患者的中风死亡率更高。

结论

癌症患者死于中风的风险明显高于一般人群。与一般人群相比，结直肠癌、肺癌和支气管癌患者因中风死亡的风险更高。