Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial.,JAMA Neurology

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Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial.
JAMA Neurology ( IF 29.0 ) Pub Date : 2023-05-08 , DOI: 10.1001/jamaneurol.2023.0997
Daniele Altomare _{1,

2,

3} , Frederik Barkhof _{4,

5} , Camilla Caprioglio _{1,

2} , Lyduine E Collij ₄ , Philip Scheltens ₆ , Isadora Lopes Alves ₄ , Femke Bouwman ₆ , Johannes Berkhof ₇ , Ingrid S van Maurik _{6,

7} , Valentina Garibotto _{8,

9} , Christian Moro _{1,

2} , Julien Delrieu _{10,

11} , Pierre Payoux _{12,

13} , Laure Saint-Aubert _{12,

13} , Anne Hitzel ₁₂ , José Luis Molinuevo _{14,

15} , Oriol Grau-Rivera _{14,

16,

17} , Juan Domingo Gispert _{14,

16,

18} , Alexander Drzezga _{19,

20,

21} , Frank Jessen _{20,

22,

23} , Philip Zeyen ₂₂ , Agneta Nordberg _{24,

25} , Irina Savitcheva ₂₆ , Vesna Jelic ₂₇ , Zuzana Walker _{28,

29} , Paul Edison ₃₀ , Jean-François Demonet ₃₁ , Rossella Gismondi ₃₂ , Gill Farrar ₃₃ , Andrew W Stephens ₃₂ , Giovanni B Frisoni _{1,

2} ,

Affiliation

Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.
Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland.
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers (UMC)-Location VUmc, Amsterdam, the Netherlands.
Institute of Neurology, Institute of Healthcare Engineering, University College London, London, United Kingdom.
Alzheimer Center, Department of Neurology, Amsterdam University Medical Centers-Location VUmc, Amsterdam, the Netherlands.
Department of Epidemiology and Data Science, Amsterdam University Medical Centers-Location VUmc, Amsterdam, the Netherlands.
Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
Gérontopôle, Department of Geriatrics, Toulouse University Hospital, Toulouse, France.
Maintain Aging Research Team, CERPOP, Inserm, Université Paul Sabatier, Toulouse, France.
Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
Toulouse NeuroImaging Center (ToNIC), UMR1214 Inserm, Université de Toulouse III, Toulouse, France.
Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
H. Lundbeck, Copenhagen, Denmark.
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.
Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain.
Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany.
Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, Germany.
Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Excellence Cluster Cellular Stress Responses in Aging-Related Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.
Department of Neurobiology, Care Sciences and Society, Center of Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Theme Aging, Karolinska University Hospital, Stockholm, Sweden.
Medical Radiation Physics and Nuclear Medicine, Section for Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.
Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden.
Division of Psychiatry, University College London, London, United Kingdom.
St Margaret's Hospital, Essex Partnership University NHS Foundation Trust, Essex, United Kingdom.
Division of Neurology, Department of Brain Sciences, Imperial College London, London, United Kingdom.
Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Life Molecular Imaging, Berlin, Germany.
GE Healthcare, Amersham, United Kingdom.

Amyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of appropriately designed studies demonstrating its clinical effect.

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