A systematic analysis of immune escape signals in the primary and metastatic tumor genome,Nature Genetics

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A systematic analysis of immune escape signals in the primary and metastatic tumor genome
Nature Genetics ( IF 31.7 ) Pub Date : 2023-05-10 , DOI: 10.1038/s41588-023-01374-2
Jimmy Van den Eynden _{1,

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Affiliation

Tumors develop mechanisms to escape immune destruction. A systematic analysis of large genome sequencing datasets shows that one in four tumors develop genetic immune escape and its prevalence is remarkably similar between primary and metastatic tumors, suggesting that immune escape is an early event during tumor evolution.

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