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A systematic analysis of immune escape signals in the primary and metastatic tumor genome
Nature Genetics ( IF 31.7 ) Pub Date : 2023-05-10 , DOI: 10.1038/s41588-023-01374-2
Jimmy Van den Eynden 1, 2
Affiliation  

Tumors develop mechanisms to escape immune destruction. A systematic analysis of large genome sequencing datasets shows that one in four tumors develop genetic immune escape and its prevalence is remarkably similar between primary and metastatic tumors, suggesting that immune escape is an early event during tumor evolution.

中文翻译:

原发性和转移性肿瘤基因组中免疫逃逸信号的系统分析

肿瘤发展出逃避免疫破坏的机制。对大型基因组测序数据集的系统分析表明,四分之一的肿瘤发生遗传免疫逃逸,其流行率在原发性和转移性肿瘤之间非常相似,这表明免疫逃逸是肿瘤进化过程中的早期事件。
更新日期:2023-05-10
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