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Enabling glucose adaptive self-healing hydrogel based triboelectric biosensor for tracking a human perspiration
Nano Energy ( IF 16.8 ) Pub Date : 2023-05-09 , DOI: 10.1016/j.nanoen.2023.108513
Pawisa Kanokpaka , Yu-Hsin Chang , Ching-Cheng Chang , Mia Rinawati , Pang-Chen Wang , Ling-Yu Chang , Min-Hsin Yeh

A breakthrough in intelligent healthcare enables the collection of real-time patient data and active diagnosis via the advancement of medical technology. Monitoring glucose levels steady is essential to minimize diabetes-related issues since glucose is used by cells as an essential source of energy. Despite the range of commercially available glucose monitoring devices, the pain of repetitive blood testing and complex power demands has addressed the shortcomings of painless compact glucose biosensors. To address these drawbacks, self-healing glucose adaptive hydrogel based triboelectric biosensors (GAH-TES) are proposed as a biocompatible noninvasive technique for simultaneous glucose monitoring. With the assistance of a -cyclodextrin inclusion complex, glucose-adaptive PVA hydrogels may be utilized as an immobilization matrix for the glucose oxidase enzyme. The modulation of dynamic hydrogel networks in the presence of diversified glucose environments leads in changes in conductivity that boost electrical performance. Introducing glucose-adaptive hydrogel into a triboelectric nanogenerator (TENG) allows for efficient energy conversion from motion-based glucose stimuli in human sweat to electrical output. Higher glucose concentrations were shown to boost TENG production due to the greater conductivity and polarization effect caused by the increased ionic strength carried by the enzymatic activity. Due to its ability to detect high glucose levels autonomously, GAH-TES has broadened the scope of diabetes management by highly selective, flexible, and reliable real-time monitoring of human perspiration.



中文翻译:

基于葡萄糖自适应自愈水凝胶的摩擦电生物传感器用于跟踪人体排汗

智能医疗领域的突破使实时患者数据的收集和主动诊断成为可能医疗技术的进步。稳定监测葡萄糖水平对于最大程度地减少糖尿病相关问题至关重要,因为葡萄糖被细胞用作重要的能量来源。尽管市售的葡萄糖监测设备种类繁多,但重复血液测试的痛苦和复杂的电力需求已经解决了无痛紧凑型葡萄糖生物传感器的缺点。为了解决这些缺点,提出了基于自修复葡萄糖自适应水凝胶的摩擦电生物传感器(GAH-TES)作为一种用于同时监测葡萄糖的生物相容性非侵入性技术。在β-环糊精包合物的帮助下,葡萄糖适应性 PVA 水凝胶可用作葡萄糖氧化酶的固定化基质。在存在多样化葡萄糖环境的情况下,动态水凝胶网络的调制会导致电导率发生变化,从而提高电性能。将葡萄糖适应性水凝胶引入摩擦纳米发电机 (TENG) 可实现从人体汗液中基于运动的葡萄糖刺激到电输出的高效能量转换。较高的葡萄糖浓度被证明可以促进 TENG 的产生,这是由于酶活性携带的离子强度增加导致的电导率和极化效应更大。由于能够自主检测高血糖水平,GAH-TES 通过高度选择性、灵活且可靠的人体排汗实时监测拓宽了糖尿病管理的范围。将葡萄糖适应性水凝胶引入摩擦纳米发电机 (TENG) 可实现从人体汗液中基于运动的葡萄糖刺激到电输出的高效能量转换。较高的葡萄糖浓度被证明可以促进 TENG 的产生,这是由于酶活性携带的离子强度增加导致的电导率和极化效应更大。由于能够自主检测高血糖水平,GAH-TES 通过高度选择性、灵活且可靠的人体排汗实时监测拓宽了糖尿病管理的范围。将葡萄糖适应性水凝胶引入摩擦纳米发电机 (TENG) 可实现从人体汗液中基于运动的葡萄糖刺激到电输出的高效能量转换。较高的葡萄糖浓度被证明可以促进 TENG 的产生,这是由于酶活性携带的离子强度增加导致的电导率和极化效应更大。由于能够自主检测高血糖水平,GAH-TES 通过高度选择性、灵活且可靠的人体排汗实时监测拓宽了糖尿病管理的范围。较高的葡萄糖浓度被证明可以促进 TENG 的产生,这是由于酶活性携带的离子强度增加导致的电导率和极化效应更大。由于能够自主检测高血糖水平,GAH-TES 通过高度选择性、灵活且可靠的人体排汗实时监测拓宽了糖尿病管理的范围。较高的葡萄糖浓度被证明可以促进 TENG 的产生,这是由于酶活性携带的离子强度增加导致的电导率和极化效应更大。由于能够自主检测高血糖水平,GAH-TES 通过高度选择性、灵活且可靠的人体排汗实时监测拓宽了糖尿病管理的范围。

更新日期:2023-05-13
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