当前位置: X-MOL 学术Eur. J. Obstet. Gynecol. Reprod. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Factors associated with spontaneous miscarriage risk in IUI treatment: A retrospectively cohort of 31,933 cycles
European Journal of Obstetrics & Gynecology and Reproductive Biology ( IF 2.1 ) Pub Date : 2023-05-09 , DOI: 10.1016/j.ejogrb.2023.05.005
Qiongxiu Luo 1 , Jiaying Qin 2 , Huan Wang 1 , Yinyan Hu 1 , Lan Yang 1 , Taifeng Mao 1 , Ling Yi 1 , Wenyan Liu 1 , Qiao Zeng 1 , Yu Qiu 1
Affiliation  

To determine the factors associated with intrauterine insemination (IUI) miscarriages and reduce the IUI miscarriage rate, a retrospective study was performed by reviewing 31,933 IUI cycles from 2006 to 2018. The overall there were 14.50% clinical pregnancies, and 16.74% miscarriages. Logistic regression revealed the following three predictive variables: females aged ≥ 35 years (odds ratio [OR] = 2.131; p < 0.001), spontaneous miscarriage history (OR = 1.513; p = 0.005), and ovarian stimulation schemes such as clomiphene citrate (CC) (OR = 1.459; p = 0.003). The natural cycle led to a lower miscarriage rate for patients without spontaneous miscarriage history both for those over 35 years old (OR = 0.402; p = 0.034) and for those under 35 years old (OR = 0.806; p = 0.017). Gonadotropin (Gn) showed the lowest miscarriage rate for patients without abortion history, though no significant differences were found. Patients under 35 with a history of miscarriage were protected from miscarriage by using CC and Gn together (OR = 0.516; p = 0.032). No significant differences were found between various ovarian protocols when patients with abortion history were aged ≥ 35 years (p = 0.606). CC + Gn showed the lowest miscarriage rate. In conclusion, the natural cycle could be suggested for infertility couples to minimize abortion risk. When ovarian induction is required, CC + Gn had the lowest miscarriage rate for women with a history of spontaneous miscarriage while Gn is more successful for individuals without such a history.



中文翻译:

IUI 治疗中与自然流产风险相关的因素:31,933 个周期的回顾性队列

为了确定与宫腔内人工授精 (IUI) 流产相关的因素并降低 IUI 流产率,通过回顾 2006 年至 2018 年的 31,933 个 IUI 周期进行了一项回顾性研究。总体而言,临床妊娠率为 14.50%,流产率为 16.74%。逻辑回归揭示了以下三个预测变量:≥ 35 岁的女性(比值比 [OR] = 2.131;p < 0.001)、自发流产史(OR = 1.513;p = 0.005)和卵巢刺激方案,例如克罗米芬柠檬酸盐( CC) (OR = 1.459; p = 0.003)。对于 35 岁以上 (OR = 0.402;p = 0.034) 和 35 岁以下 (OR = 0.806;p = 0.017) 的无自然流产史的患者,自然周期导致流产率较低。促性腺激素 (Gn) 在没有流产史的患者中流产率最低,但未发现显着差异。35 岁以下有流产史的患者联合使用 CC 和 Gn 可避免流产(OR = 0.516;p = 0.032)。当有流产史的患者年龄≥ 35 岁时,各种卵巢方案之间没有发现显着差异 (p = 0.606)。CC + Gn 显示流产率最低。总之,可以为不孕夫妇建议自然周期,以尽量减少流产风险。当需要进行卵巢诱导时,对于有自然流产史的女性,CC + Gn 的流产率最低,而对于没有自然流产史的女性,Gn 的成功率更高。35 岁以下有流产史的患者联合使用 CC 和 Gn 可避免流产(OR = 0.516;p = 0.032)。当有流产史的患者年龄≥ 35 岁时,各种卵巢方案之间没有发现显着差异 (p = 0.606)。CC + Gn 显示流产率最低。总之,可以为不孕夫妇建议自然周期,以尽量减少流产风险。当需要进行卵巢诱导时,对于有自然流产史的女性,CC + Gn 的流产率最低,而对于没有自然流产史的女性,Gn 的成功率更高。35 岁以下有流产史的患者联合使用 CC 和 Gn 可避免流产(OR = 0.516;p = 0.032)。当有流产史的患者年龄≥ 35 岁时,各种卵巢方案之间没有发现显着差异 (p = 0.606)。CC + Gn 显示流产率最低。总之,可以为不孕夫妇建议自然周期,以尽量减少流产风险。当需要进行卵巢诱导时,对于有自然流产史的女性,CC + Gn 的流产率最低,而对于没有自然流产史的女性,Gn 的成功率更高。CC + Gn 显示流产率最低。总之,可以为不孕夫妇建议自然周期,以尽量减少流产风险。当需要进行卵巢诱导时,对于有自然流产史的女性,CC + Gn 的流产率最低,而对于没有自然流产史的女性,Gn 的成功率更高。CC + Gn 显示流产率最低。总之,可以为不孕夫妇建议自然周期,以尽量减少流产风险。当需要进行卵巢诱导时,对于有自然流产史的女性,CC + Gn 的流产率最低,而对于没有自然流产史的女性,Gn 的成功率更高。

更新日期:2023-05-09
down
wechat
bug