Immunoregulation in cancer-associated cachexia,Journal of Advanced Research

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Immunoregulation in cancer-associated cachexia
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2023-05-06 , DOI: 10.1016/j.jare.2023.04.018
Qi Wu ₁ , Zhou Liu ₂ , Bei Li ₃ , Yu-E Liu ₁ , Ping Wang ₁

Affiliation

Cancer-associated cachexia is a multi-organ disorder associated with progressive weight loss due to a variable combination of anorexia, systemic inflammation and excessive energy wasting. Considering the importance of immunoregulation in cachexia, it still lacks a complete understanding of the immunological mechanisms in cachectic progression. Our aim here is to describe the complex immunoregulatory system in cachexia. We summarize the effects and translational potential of the immune system on the development of cancer-associated cachexia and we attempt to conclude with thoughts on precise and integrated therapeutic strategies under the complex immunological context of cachexia. This review is focused on three main key concepts. First, we highlight the inflammatory factors and additional mediators that have been identified to modulate this syndrome. Second, we decipher the potential role of immune checkpoints in tissue wasting. Third, we discuss the multilayered insights in cachexia through the immunometabolic axis, immune-gut axis and immune-nerve axis.

中文翻译：

癌症相关恶病质的免疫调节

癌症相关恶病质是一种多器官疾病，与厌食、全身炎症和过度能量浪费的多种组合导致的进行性体重减轻有关。考虑到免疫调节在恶病质中的重要性，目前仍缺乏对恶病质进展中免疫学机制的完整了解。我们的目的是描述恶病质中复杂的免疫调节系统。我们总结了免疫系统对癌症相关恶病质发展的影响和转化潜力，并试图总结在恶病质复杂的免疫学背景下精确和综合治疗策略的想法。本次审查重点关注三个主要概念。首先，我们强调已确定可调节该综合征的炎症因子和其他介质。其次，我们破译了免疫检查点在组织消耗中的潜在作用。第三，我们通过免疫代谢轴、免疫肠道轴和免疫神经轴讨论恶病质的多层见解。

更新日期：2023-05-06

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