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Synthesis of Spirocyclic and Fused Isoxazoline Building Blocks
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-04 , DOI: 10.1002/ejoc.202300282 Bohdan A. Chalyk 1 , Vitalii V. Izhyk 2 , Kyrylo Danyleiko 3 , Bohdan Sosunovych 4 , Bohdan V. Vashchenko 2 , Oleksandr Zginnyk 3 , Violetta Olshanska 5 , Peter Teodorovic 6 , Angelina V. Biitseva 7 , Dmitriy M. Volochnyuk 1 , Oleksandr O Grygorenko 2
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-04 , DOI: 10.1002/ejoc.202300282 Bohdan A. Chalyk 1 , Vitalii V. Izhyk 2 , Kyrylo Danyleiko 3 , Bohdan Sosunovych 4 , Bohdan V. Vashchenko 2 , Oleksandr Zginnyk 3 , Violetta Olshanska 5 , Peter Teodorovic 6 , Angelina V. Biitseva 7 , Dmitriy M. Volochnyuk 1 , Oleksandr O Grygorenko 2
Affiliation
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A scalable and efficient approach to the synthesis of fused and spirocyclic sp3-enriched isoxazoline building blocks via the 1,3-dipolar cycloaddition of functionalized chloroximes and cyclic alkenes is disclosed. The target compounds are prepared on a multigram scale, and their potential for further functionalization is revealed.
中文翻译：
螺环和稠合异恶唑啉砌块的合成
公开了一种通过功能化的氯肟和环烯烃的 1,3-偶极环加成合成稠合和螺环sp 3富集异恶唑啉结构单元的可扩展且有效的方法。目标化合物以多克规模制备，并揭示了它们进一步功能化的潜力。
更新日期：2023-05-04
中文翻译：
螺环和稠合异恶唑啉砌块的合成
公开了一种通过功能化的氯肟和环烯烃的 1,3-偶极环加成合成稠合和螺环sp 3富集异恶唑啉结构单元的可扩展且有效的方法。目标化合物以多克规模制备，并揭示了它们进一步功能化的潜力。
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