OBJECTIVE This study evaluated the efficacy of the 2GETHER relationship education and HIV prevention program for young male couples in reducing risk for HIV. METHOD We conducted a comparative effectiveness randomized controlled trial of 2GETHER, a five-session hybrid group- and couple-based intervention delivered via videoconference, relative to a single-session HIV testing and risk reduction counseling protocol delivered to couples. We randomized 200 young male couples (N = 400) to 2GETHER or control from 2018 to 2020. Primary biomedical (i.e., rectal Chlamydia and Gonorrhea infection) and behavioral outcomes (i.e., condomless anal sex [CAS]) were measured at 12-months postintervention. Secondary outcomes were other HIV prevention and risk behaviors, relationship quality, and substance use. Multilevel regression was used to model intervention outcomes to account for clustering within couples. Postintervention change over time was modeled as a latent linear growth curve at the within-persons level. RESULTS We observed significant intervention effects on primary biomedical and behavioral HIV risk outcomes. Participants in 2GETHER had significantly lower odds of rectal STIs at 12-months relative to control. We also observed significantly steeper declines in the number of CAS partners and acts from baseline to 12-month follow-up in 2GETHER relative to control. Few differences were observed for secondary relationship and HIV-related outcomes. CONCLUSIONS 2GETHER is an efficacious intervention that has a significant impact on both biomedical and behavioral HIV prevention outcomes among male couples. Couple-based HIV prevention programs enhanced with evidence-based relationship education may effectively reduce the most proximal predictors of HIV infection. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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2GETHER 的生物医学和行为结果：针对年轻男性夫妇的远程医疗艾滋病毒预防计划的随机对照试验。

目的 本研究评估了针对年轻男性夫妇的 2GETHER 关系教育和艾滋病毒预防计划在降低艾滋病毒风险方面的效果。方法 我们对 2GETHER 进行了一项有效性随机对照试验，这是一项通过视频会议提供的五期混合小组和夫妇干预措施，相对于向夫妇提供的单次艾滋病毒检测和降低风险咨询方案。我们从 2018 年至 2020 年将 200 对年轻男性夫妇 (N = 400) 随机分配至 2GETHER 组或对照组。在 12 个月时测量主要生物医学（即直肠衣原体和淋病感染）和行为结果（即无套肛交 [CAS]）干预后。次要结果是其他艾滋病毒预防和危险行为、关系质量和药物使用。使用多级回归对干预结果进行建模，以解释夫妻内的聚类。干预后随时间的变化被建模为人体内水平的潜在线性增长曲线。结果 我们观察到干预对主要生物医学和行为艾滋病毒风险结果有显着影响。与对照组相比，2GETHER 参与者在 12 个月时患直肠性传播感染的几率显着降低。我们还观察到，与对照相比，2GETHER 中 CAS 合作伙伴和行为的数量从基线到 12 个月的随访均显着急剧下降。次要关系和艾滋病毒相关结果几乎没有观察到差异。结论 2GETHER 是一种有效的干预措施，对男性夫妇的生物医学和行为艾滋病毒预防结果具有重大影响。以夫妇为基础的艾滋病毒预防计划加上基于证据的关系教育可以有效减少艾滋病毒感染的最直接预测因素。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。