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Tails don’t tell the whole story
Structure ( IF 4.4 ) Pub Date : 2023-05-04 , DOI: 10.1016/j.str.2023.03.015
Mikel Garcia-Marcos 1
Affiliation  

Before engaging G protein-coupled receptors (GPCRs) to transduce extracellular signals, heterotrimeric G proteins (Gαβγ) must fold properly with the help of chaperones. In this issue of Structure, Papasergi-Scott et al. (2023) unveil the molecular basis for how mammalian Ric-8 chaperones achieve selectivity for their respective Gα subunit clients.



中文翻译:

尾巴并不能说明全部故事

在 G 蛋白偶联受体 (GPCR) 参与转导细胞外信号之前,异三聚体 G 蛋白 (Gαβγ) 必须在分子伴侣的帮助下正确折叠。在本期《结构》中,Papasergi-Scott 等人。(2023) 揭示了哺乳动物 Ric-8 伴侣如何对其各自的 Gα 亚基客户实现选择性的分子基础。

更新日期:2023-05-05
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