In this issue of Structure, Huber et al. identify five O-methyltransferases, and three of them catalyze the sequential methylation of the Gram-negative bacterium-derived aromatic polyketide anthraquinone AQ-256. They present co-crystal structures with bound AQ-256 and its methylated derivatives, which explains the specificities of these O-methyltransferases.

中文翻译：

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O-甲基转移酶选择性修饰蒽醌天然产物

在本期结构中，Huber 等人。鉴定出五种O -甲基转移酶，其中三种催化革兰氏阴性菌衍生的芳香族聚酮化合物蒽醌 AQ-256 的顺序甲基化。他们展示了与 AQ-256 及其甲基化衍生物结合的共晶结构，这解释了这些O -甲基转移酶的特异性。