Basicity-Controlled [3+2] Cyclization of 3-Hydroxyquinolin-ones and β-Chlorinated Nitrostyrenes,European Journal of Organic Chemistry

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Basicity-Controlled [3+2] Cyclization of 3-Hydroxyquinolin-ones and β-Chlorinated Nitrostyrenes
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-05-03 , DOI: 10.1002/ejoc.202300218
Jiamin Wu ₁ , Fei Hu ₂ , Guishun Bai ₃ , Yang Yang ₃ , Damien Bonne ₄ , Jean Rodriguez ₄ , Congyong Yue ₅ , Hong Wang ₃ , Xiaoze Bao ₆

Affiliation

The construction of intriguing scaffolds through the recombination of natural products fragments are important both in organic and medicinal chemistry. Herein, a basicity-controlled synthesis of (dihydro)furo[2,3-c]quinolin-4(5H)-one derivatives through (3+2) cyclization between 3-hydroxyquinolin-2-ones and β-chlorinated nitrostyrenes was developed.

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