Design, Synthesis and Biological Evaluation of Novel Catalpol Derivatives as Potential Pancreatic Cancer Inhibitors,Chemistry - An Asian Journal

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Design, Synthesis and Biological Evaluation of Novel Catalpol Derivatives as Potential Pancreatic Cancer Inhibitors
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2023-05-02 , DOI: 10.1002/asia.202300185
Yuanfang Kong ₁ , Shuanglin Liu _{1,

2,

3} , Shaopei Wang _{1,

2,

3} , Jindan Xu _{1,

2,

3} , Yulong Hu _{1,

2,

3} , Shiqing Jiang ₁ , Chunhong Dong _{1,

2,

3}

Affiliation

Catalpol isolated from Radix Rehmanniae has a variety of biological activities. A series of C10-position imidazole-modified catalpol derivatives are specifically synthesized for serving as potential pancreatic cancer inhibitors. Through molecular docking and MTT activity screening, the optimal compound was screened, which could potentially develop into anti-pancreatic cancer drug candidates.

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