CD8 T cells recognize cancers when they detect antigenic peptides presented on a tumor’s surface MHC-I molecules. Since MHC-I antigen presentation is not essential for cell growth or survival, many cancers inactivate this pathway, and thereby escape control by CD8 T cells. Such immune evasion allows cancers to progress and also become resistant to CD8 T- cell-based immunotherapies, such as checkpoint blockade. Here, we review recent findings about the various different mechanisms that cancers use to impair antigen presentation, the consequence of such changes, and, in some cases, the potential to reverse these defects.

中文翻译：

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通过 MHC I 类抗原呈递的丧失来逃避肿瘤免疫

当 CD8 T 细胞检测到肿瘤表面 MHC-I 分子上存在的抗原肽时，它们就会识别癌症。由于 MHC-I抗原呈递对于细胞生长或生存并不是必需的，因此许多癌症使该途径​​失活，从而逃脱 CD8 T 细胞的控制。这种免疫逃避使得癌症进展，并且对基于 CD8 T 细胞的免疫疗法（例如检查点封锁）产生耐药性。在这里，我们回顾了关于癌症用来损害抗原呈递的各种不同机制、此类变化的后果以及在某些情况下逆转这些缺陷的潜力的最新发现。