Deep-red Emitting Ir(III) Complexes as Type-I Photosensitizers for Lipid Droplets Targeted Photodynamic Therapy,Chemistry - An Asian Journal

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Deep-red Emitting Ir(III) Complexes as Type-I Photosensitizers for Lipid Droplets Targeted Photodynamic Therapy
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2023-04-27 , DOI: 10.1002/asia.202300175
Jialin Tong ₁ , Ao Liu ₁ , Shanshan Huang ₁ , Yaxuan Yao ₁ , Guo-Gang Shan ₁ , Zhong-Min Su ₂

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Type-I photosensitizers have attracted much attention in photodynamic therapy (PDT) due to the advantage of negligible oxygen dependence. In this work, two deep red-emitting Ir(III) complexes have been synthesized and exhibited type I O₂⋅⁻ and ⋅OH generation ability. The excellent biocompatibility and cellular phototoxicity endow them highly applicable to lipid droplets targeted PDT.

中文翻译：

发射深红色的 Ir(III) 配合物作为 I 型光敏剂用于脂滴靶向光动力治疗

由于可忽略氧气依赖性的优势，I 型光敏剂在光动力疗法 (PDT) 中备受关注。在这项工作中，合成了两种发射深红色的 Ir(III) 配合物，并表现出 IO ₂ ⋅ ⁻型和 ⋅ OH 生成能力。优异的生物相容性和细胞光毒性赋予它们高度适用于脂滴靶向PDT。

更新日期：2023-04-27

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