Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RNA modifications modulate the immune milieu of the tumor microenvironment and point out outstanding research questions.

中文翻译：

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免疫系统中的 RNA 修饰


RNA修饰的表征确定了它们的分布特征和分子功能。各种形式的RNA修饰的动态变化对于免疫系统的发育和功能至关重要。在这篇综述中，我们讨论了创新 RNA 修饰分析技术的价值，以揭示健康和患病环境中各种免疫细胞中这些多样化、动态 RNA 修饰的功能。此外，我们探讨了目前对异常 RNA 修饰调节肿瘤微环境免疫环境机制的理解，并指出了突出的研究问题。