Protein-losing gastroenteropathies are characterized by an excessive loss of serum proteins into the gastrointestinal tract, resulting in hypoalbuminemia. Some rare cases are complicated with ischemic stroke. We report a 24-year-old woman who developed acute dysarthria and right hemiplegia 4 months after delivering her first baby by cesarean section. Diffusion-weighted magnetic resonance imaging showed a high-intensity signal in the left anterior cerebral artery territory and middle cerebral artery territory. She had marked hypoalbuminemia and decreased protein S activity. We identified protein-losing gastroenteropathy as the cause of the hypoalbuminemia, and she had a missense mutation of the PROS 1 gene, which was associated with decreased protein S activity. We speculated that the development of protein-losing gastroenteropathy accelerated the decline in protein S activity and caused cerebral infarction.

蛋白质丢失性胃肠病的特征是血清蛋白质过度丢失到胃肠道，导致低白蛋白血症。一些罕见的病例并发缺血性中风。我们报告了一名 24 岁的女性，她在剖腹产第一个孩子后 4 个月出现了急性构音障碍和右侧偏瘫。弥散加权磁共振成像显示左侧大脑前动脉区和大脑中动脉区有高强度信号。她有明显的低白蛋白血症和蛋白 S 活性降低。我们确定蛋白丢失性胃肠病是低白蛋白血症的原因，她有PROS 1 基因的错义突变，这与蛋白 S 活性降低有关。我们推测，蛋白丢失性胃肠病的发展加速了蛋白S活性的下降，导致了脑梗塞。