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Catalytic Approaches to Chemo- and Site-Selective Transformation of Carbohydrates
Chemical Reviews ( IF 51.4 ) Pub Date : 2023-04-26 , DOI: 10.1021/acs.chemrev.2c00892
Kenzo Yamatsugu 1 , Motomu Kanai 1
Affiliation  

Carbohydrates are a fundamental unit playing pivotal roles in all the biological processes. It is thus essential to develop methods for synthesizing, functionalizing, and manipulating carbohydrates for further understanding of their functions and the creation of sugar-based functional materials. It is, however, not trivial to develop such methods, since carbohydrates are densely decorated with polar and similarly reactive hydroxy groups in a stereodefined manner. New approaches to chemo- and site-selective transformations of carbohydrates are, therefore, of great significance for revolutionizing sugar chemistry to enable easier access to sugars of interest. This review begins with a brief overview of the innate reactivity of hydroxy groups of carbohydrates. It is followed by discussions about catalytic approaches to enhance, override, or be orthogonal to the innate reactivity for the transformation of carbohydrates. This review avoids making a list of chemo- and site-selective reactions, but rather focuses on summarizing the concept behind each reported transformation. The literature references were sorted into sections based on the underlying ideas of the catalytic approaches, which we hope will help readers have a better sense of the current state of chemistry and develop innovative ideas for the field.

中文翻译:

碳水化合物化学和位点选择性转化的催化方法

碳水化合物是在所有生物过程中发挥关键作用的基本单位。因此,有必要开发合成、功能化和操纵碳水化合物的方法,以进一步了解它们的功能和创建糖基功能材料。然而,开发这种方法并非易事,因为碳水化合物以立体定义的方式密集地装饰着极性和类似反应性的羟基。因此,碳水化合物化学和位点选择性转化的新方法对于革新糖化学以实现更容易获得感兴趣的糖具有重要意义。本综述首先简要概述碳水化合物的羟基的固有反应性。随后是关于催化方法的讨论,以增强、超越、或与碳水化合物转化的先天反应性正交。这篇综述避免列出化学和位点选择性反应,而是侧重于总结每个报告的转化背后的概念。参考文献根据催化方法的基本思想分为几个部分,我们希望这将帮助读者更好地了解化学的现状并为该领域开发创新思想。
更新日期:2023-04-26
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