Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme-Responsive “Covalent-Assembly” Fluorescent Probes with Tailor-Made Properties**,Chemistry - An Asian Journal

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Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme-Responsive “Covalent-Assembly” Fluorescent Probes with Tailor-Made Properties**
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2023-04-24 , DOI: 10.1002/asia.202300258
Kévin Renault _{1,

2} , Yoan Capello ₁ , Shun Yao ₃ , Sami Halila ₃ , Anthony Romieu ₁

Affiliation

The missing link!!! A carboxylic acid functionalized Meldrum's acid derivative (3-(2-methyl-4,6-dioxo-1,3-dioxan-2-yl)propanoic acid) was identified as a valuable building block to achieve facile late-stage functionalization of enzyme-responsive “covalent-assembly” probes whose activation produces fluorescent coumarin or pyronin dyes. The ability of such cyclic C-nucleophile to promote both in situ formation of a photoactive compound and release of a molecule of interest will facilitate the implementation of “covalent-assembly” principle to small-molecule based theranostics.

中文翻译：

亚芳基 Meldrum 酸：用于设计具有定制特性的酶响应“共价组装”荧光探针的多功能结构基序**

缺失的环节！！！一种羧酸功能化的 Meldrum 酸衍生物 (3-(2-methyl-4,6-dioxo-1,3-dioxan-2-yl)propanoic acid) 被确定为一种有价值的构建块，可轻松实现酶的后期功能化-响应性“共价组装”探针，其激活产生荧光香豆素或焦宁染料。这种环状 C-亲核试剂促进光敏化合物原位形成和目标分子释放的能力将促进“共价组装”原理对基于小分子的治疗诊断学的实施。

更新日期：2023-04-24

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