Chemical Sensors using Single-Molecule Electrical Measurements,Chemistry - An Asian Journal

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Chemical Sensors using Single-Molecule Electrical Measurements
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2023-04-20 , DOI: 10.1002/asia.202300181
Ruiqin Sun ₁ , Jieyao Lv ₁ , Xinyi Xue ₁ , Shiyong Yu ₁ , Zhibing Tan ₁

Affiliation

Chemical sensors using single-molecule electrical measurements are achieved by rational design of probe molecule and electrode binding structures, and the probe molecule can capture a single target molecule through intermolecular interactions. By detecting the changes in tunneling current of a probing single-molecule junction before and after being interfered with the target molecule, it can be used for realizing the application of single-molecule electrical sensors in the fields of ions, small molecules, oligomers, genetic material, and proteins. We outline the main advances, potential, and remaining challenges of qualitative identification and recognition at the single-molecule level.

中文翻译：

使用单分子电学测量的化学传感器

利用单分子电学测量的化学传感器是通过合理设计探针分子和电极结合结构来实现的，探针分子可以通过分子间相互作用捕获单个目标分子。通过检测探测单分子结受到目标分子干扰前后隧道电流的变化，可实现单分子电传感器在离子、小分子、低聚物、遗传等领域的应用。物质和蛋白质。我们概述了单分子水平定性识别和识别的主要进展、潜力和剩余挑战。

更新日期：2023-04-20

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