Without the use of chemical oxidants and metal catalysts, an aqueous electrochemical synthesis of 5-trifluoromethyluracil in batch and continuous flow was reported. The green and economically friendly approach employing commercially available CF₃SO₂Na as a CF₃ source and cheap (NH₄)₂SO₄ as a supporting electrolyte afforded the 5-trifluoromethyluracil in 10 g scale in batch electrolysis. The continuous flow-electrolysis technique was employed to further facilitate the scale-up synthesis of 5-trifluoromethyluracil.

中文翻译：

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分批连续流水相电化学合成 5-三氟甲基尿嘧啶

在不使用化学氧化剂和金属催化剂的情况下，5-三氟甲基尿嘧啶的分批和连续流水电化学合成被报道。使用市售的 CF ₃ SO ₂ Na 作为 CF ₃源和廉价的 (NH ₄ ) ₂ SO ₄作为支持电解质的绿色且经济友好的方法在分批电解中提供了 10 g 规模的 5-三氟甲基尿嘧啶。采用连续流动电解技术进一步促进 5-三氟甲基尿嘧啶的放大合成。