Pharmaceuticals have been developed for the treatment of a wide range of bone diseases and disorders, but suffer from problematic delivery to the bone marrow. Neutrophils are naturally trafficked to the bone marrow and can cross the bone marrow–blood barrier. Here we report the use of neutrophils for the targeted delivery of free drugs and drug nanoparticles to the bone marrow. We demonstrate how drug-loaded poly(lactic-co-glycolic acid) nanoparticles are taken up by neutrophils and are then transported across the bone marrow–blood barrier to boost drug concentrations in the bone marrow. We demonstrate application of this principle to two models. In a bone metastasis cancer model, neutrophil delivery is shown to deliver cabazitaxel and significantly inhibit tumour growth. In an induced osteoporosis model, neutrophil delivery of teriparatide is shown to significantly increase bone mineral density and alleviate osteoporosis indicators.

已经开发出用于治疗多种骨骼疾病和病症的药物，但它们向骨髓的输送存在问题。嗜中性粒细胞自然地被运送到骨髓并且可以穿过骨髓-血屏障。在这里，我们报告了使用嗜中性粒细胞将游离药物和药物纳米颗粒靶向递送至骨髓。我们展示了负载药物的聚（乳酸-乙醇酸共聚物）纳米颗粒如何被中性粒细胞吸收，然后被转运穿过骨髓-血屏障以提高骨髓中的药物浓度。我们演示了将此原理应用于两个模型。在骨转移癌模型中，嗜中性粒细胞递送显示递送卡巴他赛并显着抑制肿瘤生长。在诱发性骨质疏松症模型中，