Objective To assess the impact of delayed invitation on screen-detected and interval colorectal cancers (CRC) within a faecal immunochemical testing (FIT)-based CRC screening programme. Design All individuals that participated in 2017 and 2018 with a negative FIT and were eligible for CRC screening in 2019 and 2020 were included using individual-level data. Multivariable logistic regression analyses were used to assess the association between either the different time periods (ie, ‘ before ’, ‘ during ’ and ‘ after ’ the first COVID-19 wave) or the invitation interval on screen-detected and interval CRCs. Results Positive predictive value for advanced neoplasia (AN) was slightly lower during (OR=0.91) and after (OR=0.95) the first COVID-19 wave, but no significant difference was observed for the different invitation intervals. Out of all individuals that previously tested negative, 84 (0.004%) had an interval CRC beyond the 24 months since their last invitation. The time period of invitation as well as the extended invitation interval was not associated with detection rates for AN and interval CRC rate. Conclusion The impact of the first COVID-19 wave on screening yield was modest. A very small proportion of the FIT negatives had an interval CRC possibly due to an extended interval, which potentially could have been prevented if they had received the invitation earlier. Nonetheless, no increase in interval CRC rate was observed, indicating that an extended invitation interval up to 30 months had no negative impact on the performance of the CRC screening programme and a modest extension of the invitation interval seems an appropriate intervention. Data may be obtained from a third party and are not publicly available. Researchers had access to the data for the purpose of evaluation of the national colorectal cancer screening programme. The data are owned by Bevolkingsonderzoek Nederland (BVO-NL) and stored in the national screening database (ScreenIT). Researchers interested in accessing and analysing the data may contact the data officer of BVO-NL (wetenschappelijkonderzoek@bevolkingsonderzoeknederland.nl).

中文翻译：

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荷兰结直肠癌筛查计划中延迟筛查邀请对筛查检测到的癌症和间隔期癌症的影响：个人数据分析

目的 在基于粪便免疫化学检测 (FIT) 的 CRC 筛查计划中，评估延迟邀请对筛查检出和间期结直肠癌 (CRC) 的影响。设计使用个人层面的数据纳入 2017 年和 2018 年参与且 FIT 为负且有资格在 2019 年和 2020 年接受 CRC 筛查的所有个人。使用多变量逻辑回归分析来评估不同时间段（即第一波 COVID-19 波“之前”、“期间”和“之后”）或屏幕检测的邀请间隔和间隔 CRC 之间的关联。结果 晚期肿瘤 (AN) 的阳性预测值在第一波 COVID-19 期间 (OR=0.91) 和之后 (OR=0.95) 略低，但不同邀请间隔没有观察到显着差异。在之前检测呈阴性的所有个体中，有 84 人 (0.004%) 的 CRC 间隔时间超出了自上次邀请以来的 24 个月。邀请时间段以及延长的邀请间隔与AN检测率和间隔CRC率无关。结论 第一波 COVID-19 对筛查率的影响不大。极少数 FIT 阴性者可能由于间隔时间延长而出现间隔 CRC，如果他们早点收到邀请，则可能可以避免这种情况。尽管如此，没有观察到间隔 CRC 率增加，这表明将邀请间隔延长至 30 个月对 CRC 筛查计划的绩效没有负面影响，适度延长邀请间隔似乎是适当的干预措施。数据可能从第三方获得，并且不公开。研究人员获得这些数据是为了评估国家结直肠癌筛查计划。该数据归 Bevolkingsonderzoek Nederland (BVO-NL) 所有，并存储在国家筛查数据库 (ScreenIT) 中。对访问和分析数据感兴趣的研究人员可以联系 BVO-NL 的数据官员 (wetenschappelijkonderzoek@bevolkingsonderzoeknederland.nl)。