ABSTRACT

Objective

This study evaluated various biological parameters in subjects exposed to hypoxia, to verify effective monitoring for early hypoxia detection.

Background

Hypoxic-hypoxia is a life-threatening condition, but no method of early detection in flight has been established.

Method

Six healthy male subjects underwent 2 experiments at different oxygen concentrations (O₂) during hypoxic exposure on different days. Subjects inhaled approximately 21% O₂ for 3 minutes, hypoxia using approximately 14% O₂ in Experiment 1 and 7% O₂ in Experiment 2 for 3.5 minutes using a reduced oxygen breathing device. During the experiments, pupil diameter (PD), cerebral oxygenated hemoglobin (O₂Hb), peripheral tissue oxygen saturation (SpO₂), heart rate (HR), and blood pressure (BP) were measured.

Results

All 6 subjects completed both Experiments 1 and 2. ΔO₂Hb showed significant correlations with %HR (r = −0.6005, P < .0001), %PD (r = −0.5227, P = .0001), and %SpO₂ (r = 0.8281, P < .0001) in Experiment 1. ΔO₂Hb also showed significant correlations with %HR (r = −0.7904, P < .0001), %PD (r = −0.7933, P < .0001), and %SpO₂ (r = 0.7240, P < .0001) in Experiment 2. Rapid hypoxic exposure caused increase in %PD and decrease in ΔO₂Hb, followed by immediate increase in %HR, and then decrease in %SpO₂.

Conclusion

The present study suggested that monitoring of HR, PD, and O₂Hb were earlier parameters to detect hypoxia than SpO_2.

中文翻译：

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有效监测及早发现战斗机飞行员缺氧

摘要

客观的

本研究评估了暴露于缺氧的受试者的各种生物参数，以验证早期缺氧检测的有效监测。

背景

缺氧是一种危及生命的疾病，但目前还没有建立在飞行中早期检测的方法。

方法

六名健康男性受试者在不同天的低氧暴露期间在不同氧气浓度（O ₂ ）下进行了两次实验。受试者吸入约21% O ₂ 3分钟，使用减氧呼吸装置在实验1中使用约14% O ₂和在实验2中使用约7% O _{2缺氧3.5分钟。}实验期间测量瞳孔直径（PD）、脑氧合血红蛋白（O ₂ Hb）、周围组织氧饱和度（SpO ₂）、心率（HR）和血压（BP）。

结果

所有 6 名受试者均完成了实验 1 和 2。ΔO ₂ Hb 显示与 %HR (r = -0.6005，P < .0001)、%PD (r = -0.5227，P = .0001) 和 %SpO ₂ (实验 1 中，r = 0.8281，P < .0001)。ΔO ₂ Hb 还显示与 %HR (r = -0.7904，P < .0001)、%PD (r = -0.7933，P < .0001) 和实验 2 中的%SpO ₂ (r = 0.7240，P < .0001)。快速缺氧导致 %PD 增加和 ΔO ₂ Hb 减少，随后 %HR 立即增加，然后 %SpO ₂减少。

结论

本研究表明，监测 HR、PD 和 O _{2 Hb 是比 SpO 2}更早检测缺氧的参数。