Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications,Chemical Reviews

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Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications
Chemical Reviews ( IF 51.4 ) Pub Date : 2023-04-18 , DOI: 10.1021/acs.chemrev.2c00649
R Tyler Mertens ₁ , Sailajah Gukathasan ₁ , Adedamola S Arojojoye ₁ , Chibuzor Olelewe ₁ , Samuel G Awuah _{1,

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Affiliation

The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of inflammatory arthritis including rheumatoid and juvenile arthritis; however, new gold agents have been slow to enter the clinic. Repurposing of auranofin in different disease indications such as cancer, parasitic, and microbial infections in the clinic has provided impetus for the development of new gold complexes for biomedical applications based on unique mechanistic insights differentiated from auranofin. Various chemical methods for the preparation of physiologically stable gold complexes and associated mechanisms have been explored in biomedicine such as therapeutics or chemical probes. In this Review, we discuss the chemistry of next generation gold drugs, which encompasses oxidation states, geometry, ligands, coordination, and organometallic compounds for infectious diseases, cancer, inflammation, and as tools for chemical biology via gold–protein interactions. We will focus on the development of gold agents in biomedicine within the past decade. The Review provides readers with an accessible overview of the utility, development, and mechanism of action of gold-based small molecules to establish context and basis for the thriving resurgence of gold in medicine.

中文翻译：

下一代黄金药物和探针：化学和生物医学应用

黄金药物硫代苹果酸金钠（Myocrisin）、金硫葡萄糖（Solganal）和口服金诺芬（Ridaura）在现代医学中用于治疗炎症性关节炎，包括类风湿性关节炎和幼年关节炎；然而，新的黄金药剂进入临床的速度却很缓慢。在临床上，金诺芬在癌症、寄生虫和微生物感染等不同疾病适应症中的重新利用，基于不同于金诺芬的独特机制见解，为生物医学应用的新型金配合物的开发提供了动力。生物医学领域已经探索了制备生理稳定的金配合物的各种化学方法和相关机制，例如治疗学或化学探针。在这篇综述中，我们讨论了下一代金药物的化学，其中包括用于传染病、癌症、炎症的氧化态、几何结构、配体、配位和有机金属化合物，以及通过金-蛋白质相互作用作为化学生物学工具。十年内我们将重点发展生物医药黄金制剂。该评论为读者提供了关于金基小分子的实用性、发展和作用机制的简单概述，为金在医学领域的蓬勃复兴奠定了背景和基础。

更新日期：2023-04-18

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