The concomitant presence of Castleman disease with other hematological pathology is an event described in the literature with increasing frequency, able to modify the diagnostic and curative approach in such patients. Very few studies in the literature describe the association of CD with concomitant neoplastic diseases: the most frequent are Kaposi’s sarcomas (especially in HIV and HHV-8 positive patients) and lymphoproliferative disorders, such as lymphomas. Instead, since the association with plasma cell diseases such as multiple myeloma and plasmacytoma is infrequent, there is lacking literature. This manuscript aims to revise the literature by describing a rare case of CD and plasmacytoma and attempting to explain the underlying triggering mechanisms.


中文翻译：

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多中心Castleman病与并发血液病：浆细胞瘤的发生及文献综述的假设

文献中描述的卡斯尔曼病与其他血液病理学同时存在的事件越来越频繁，能够改变此类患者的诊断和治疗方法。文献中很少有研究描述 CD 与伴随肿瘤疾病的关联：最常见的是卡波西肉瘤（尤其是 HIV 和 HHV-8 阳性患者）和淋巴组织增生性疾病，例如淋巴瘤。相反，由于与多发性骨髓瘤和浆细胞瘤等浆细胞疾病的关联并不常见，因此缺乏文献。本手稿旨在通过描述 CD 和浆细胞瘤的罕见病例并试图解释潜在的触发机制来修订文献。