Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease that continues to develop new variants. A crucial step in the quest to reduce the infection is the development of rapid and reliable virus detectors. Here, we report a chip scale photonic sensing device consisting of a silicon-nitride double microring resonator (MRR) for detecting SARS-CoV-2 in clinical samples. The sensor is implemented by surface activation of one of the MRRs, acting as a probe, with DNA primers for SARS-CoV-2 RNA, whereas the other MRR is used as a reference. The performance of the sensor is determined by applying different amounts of SARS-CoV-2 complementary RNA. As will be shown in the paper, our device detects the RNA fragments at concentrations of 10 cp/μL and with sensitivity of 750 nm/RIU. As such, it shows a promise toward the implementation of label-free, small form factor, CMOS compatible biosensor for SARS-CoV-2, which is also environment, temperature, and pressure independent. Our approach can also be used for detecting other SARS-CoV-2 genes, as well as other viruses and pathogens.

中文翻译：

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基于氮化硅双微环谐振器的片上多元 COVID 19 光子传感器

2019 年冠状病毒病 (COVID-19) 是一种新出现的人类传染病，并不断发展出新的变种。寻求减少感染的关键步骤是开发快速可靠的病毒检测器。在这里，我们报告了一种由氮化硅双微环谐振器 (MRR) 组成的芯片级光子传感装置，用于检测临床样本中的 SARS-CoV-2。该传感器通过表面激活其中一个 MRR 来实现，作为探针，使用 SARS-CoV-2 RNA 的 DNA 引物，而另一个 MRR 用作参考。传感器的性能通过应用不同量的 SARS-CoV-2 互补 RNA 来确定。如本文中所示，我们的设备检测浓度为 10 cp/μL 且灵敏度为 750 nm/RIU 的 RNA 片段。像这样，它显示了为 SARS-CoV-2 实现无标签、小尺寸、CMOS 兼容生物传感器的承诺，它也与环境、温度和压力无关。我们的方法还可用于检测其他 SARS-CoV-2 基因，以及其他病毒和病原体。