Ecklonia cava subsp. kurome (EK) and E. cava subsp. stolonifera (ES) are rich in phlorotannins and water-soluble polysaccharides (alginates, laminarans and fucoidans). Total phenolic content (TPC), antioxidant (O₂⁻ radical scavenging and Fe-reducing) and anti-glycation (bovine serum albumin-fructose model) capacities of dried EK and ES were higher than those of Eisenia bicyclis and Eisenia nipponica in vitro (p < 0.05). To clarify the effect of EK and ES on gut microbiota, 5% (w/w) EK or ES was administered to Institute of Cancer Research mice fed a high-sucrose and low-dietary fibre diet for 14 days and their caecal microbiota was analysed using 16S rDNA (V4) amplicon sequencing. The amplicon sequence variant (ASV) numbers of the EK and ES groups were 4- and 2-fold lower than those of the no fibre (NF) diet group. Bacteroidota containing alginate- and laminaran-degrading microbes, such as Bacteroides acidifaciens- and B. intestinalis-like bacteria, were more abundant in EK and ES groups than in the NF group. Faecalibaculum rodentium- and Akkermansia muciniphila-like bacteria were also more abundant in EK and ES groups than in the NF group. These EK- and ES-responsive indigenous gut bacteria have been regarded as beneficial commensal for host health. Further studies on EK and ES including investigation of dose-dependent effects are needed.

腔昆布亚种。kurome (EK) 和E. cava亚种。stolonifera (ES) 富含根皮单宁和水溶性多糖（藻酸盐、昆布多糖和褐藻糖胶）。干燥的 EK 和 ES的总酚含量 (TPC)、抗氧化（O ₂ ^-自由基清除和 Fe 还原）和抗糖化（牛血清白蛋白-果糖模型）能力在体外高于Eisenia bicyclis和Eisenia nipponica （ p  < 0.05）。为了阐明 EK 和 ES 对肠道微生物群的影响，将 5% (w/w) EK 或 ES 给予癌症研究所小鼠，喂食高蔗糖和低膳食纤维饮食 14 天，并分析了它们的盲肠微生物群使用 16S rDNA (V4) 扩增子测序。EK 和 ES 组的扩增子序列变异 (ASV) 数量比无纤维 (NF) 饮食组低 4 倍和 2 倍。含有藻酸盐和昆布多糖降解微生物的拟杆菌门，如嗜酸拟杆菌和肠类拟杆菌，在 EK 和 ES 组中比在 NF 组中更丰富。Faecalibaculum rodentium-和Akkermansia muciniphila类细菌在 EK 和 ES 组中也比在 NF 组中更丰富。这些对 EK 和 ES 有反应的本土肠道细菌被认为是有益于宿主健康的共生菌。需要对 EK 和 ES 进行进一步研究，包括研究剂量依赖性效应。