It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jiménez-Moreno et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.201910133) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for LMX1B-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons.

中文翻译：

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LC3B 是多巴胺能神经元中 LMX1B 介导的自噬基因转录的辅助因子

人们越来越清楚，自噬蛋白 Atg8 家族不仅在细胞质中发挥作用，而且在细胞核中也发挥作用。在本期中，Jiménez-Moreno 等人。 (2023. J. Cell Biol.https://doi.org/10.1083/jcb.201910133) 报道核 LC3B 与 LIM 同源域转录因子 LMX1B 结合，并作为 LMX1B 介导的自噬基因转录的辅助因子，提供应激保护并确保中脑多巴胺能神经元的存活。