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Catching active enhancers via H2B N-terminal acetylation
Nature Genetics ( IF 31.7 ) Pub Date : 2023-04-06 , DOI: 10.1038/s41588-023-01347-5
Chang Huang 1 , Kristian Helin 1
Affiliation  

Specific chromatin features, especially histone H3 lysine 27 acetylation, are widely used to identify active enhancers, yet current methods are imprecise. New work suggests that histone H2B N terminus multisite lysine acetylation (H2BNTac) is a notable signature of active enhancers and could substantially improve enhancer prediction.

中文翻译:

通过 H2B N-末端乙酰化捕获活性增强剂

特定染色质特征,尤其是组蛋白 H3 赖氨酸 27 乙酰化,被广泛用于识别活性增强子,但目前的方法并不精确。新研究表明,组蛋白 H2B N 末端多位点赖氨酸乙酰化 (H2BNTac) 是活性增强子的显着特征,可以显着改善增强子预测。
更新日期:2023-04-08
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