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A twist to splicing regulation in haematopoiesis
Nature Cell Biology ( IF 17.3 ) Pub Date : 2023-04-06 , DOI: 10.1038/s41556-022-01043-2
Maria Carmo-Fonseca 1
Affiliation  

DNMT3A is best known for its de novo DNA methyltransferase activity. But a new study shows that the protein also has a role in RNA splicing during activation of embryonic and haematopoietic stem cells. This introduces a new perspective for approaching diseases associated with DNMT3A mutations.

中文翻译:

造血作用中剪接调控的转折

DNMT3A 以其从头 DNA 甲基转移酶活性而闻名。但是一项新的研究表明,该蛋白质在胚胎和造血干细胞激活过程中也对 RNA 剪接起作用。这为处理与 DNMT3A 突变相关的疾病引入了新的视角。
更新日期:2023-04-08
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