Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhesion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomaterial interactions and provides specific knowledge of conditions to modulate the macrophage response.

生物医学植入物的有效整合需要了解和控制细胞与植入物表面之间的相互作用。高通量筛选和建模可以识别引发所需细胞行为的特性，并揭示模式以支持通用设计规则的未来发展。最近在Matter中，Vassey 等人。开发了 ChemoArchiChip 来研究具有不同材料化学的微型 3D 物体对巨噬细胞粘附和极化的影响。该研究显示了筛选和建模的能力，以产生对细胞-生物材料相互作用的理解，并提供调节巨噬细胞反应的条件的具体知识。