The route design and process development for the synthesis of BI 1702135 are described. The synthetic design centers around an amide synthesis involving a 2-amino benzimidazole analog 4 that has two competing acylation sites. A highly selective acylation protocol at the desired N-2′ site was identified. Robust and convenient processes were developed for each step in this five-step synthesis of BI 1702135.

中文翻译：

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BI 1702135 的合成工艺开发：通过 2-氨基苯并咪唑中间体的选择性酰化实现的简洁设计

描述了BI 1702135的合成路线设计和工艺开发。合成设计以酰胺合成为中心，涉及具有两个竞争性酰化位点的2-氨基苯并咪唑类似物4 。确定了所需 N-2' 位点的高选择性酰化方案。为BI 1702135的五步合成中的每一步开发了稳健且方便的流程。