Focal Cortex Stimulation With a Novel Implantable Device and Antiseizure Outcomes in 2 Prospective Multicenter Single-Arm Trials.,JAMA Neurology

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Focal Cortex Stimulation With a Novel Implantable Device and Antiseizure Outcomes in 2 Prospective Multicenter Single-Arm Trials.
JAMA Neurology ( IF 20.4 ) Pub Date : 2023-04-03 , DOI: 10.1001/jamaneurol.2023.0066
Andreas Schulze-Bonhage _{1,

2,

3,

4} , Martin Hirsch ₁ , Susanne Knake ₅ , Elisabeth Kaufmann ₆ , Josua Kegele ₇ , Michael Rademacher ₈ , Kristl Vonck ₉ , Volker Arnd Coenen _{10,

11,

12} , Martin Glaser ₁₃ , Carolin Jenkner _{14,

15} , Yaroslav Winter _{5,

15} , Sergiu Groppa ₁₆ ,

Affiliation

Epilepsy Center, Neurocenter, University Medical Center, University of Freiburg, Freiburg, Germany.
NeuroModul Basic, University of Freiburg, Freiburg, Germany.
Bernstein Center of Computational Neuroscience, University of Freiburg, Freiburg, Germany.
European Reference Network EpiCare.
Neurology, University Hospital Marburg, Marburg, Germany.
Department of Neurology, University Hospital, Ludwig-Maximilan's University, Munich, Germany.
Hertie Institute for Clinical Brain Research, Department of Neurology and Epileptology, University of Tübingen, Tübingen, Germany.
Epileptology, University Hospital Bonn, Bonn, Germany.
Neurology, University Hospital Ghent, Ghent, Belgium.
Department of Stereotactic and Functional Neurosurgery, Medical Center of the University of Freiburg, Freiburg, Germany.
Medical Faculty of the University of Freiburg, Frieburg im Breisgau, Germany.
Center for Deep Brain Stimulation, Medical Center of the University of Freiburg, Freiburg, Germany.
Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.
Study Center, University Medical Center, University of Freiburg, Freiburg, Germany.
Mainz Comprehensive Epilepsy and Sleep Medicine Center, Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Neurology, University Hospital Mainz, Mainz, Germany.

For the large population of people with drug-refractory epilepsy, alternative treatment approaches are needed. Clinical trial outcomes of a novel stimulation device, which is newly available in Europe for the treatment of patients with a predominant seizure focus, are reported for the first time.

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