Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.,JAMA Neurology

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Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.
JAMA Neurology ( IF 20.4 ) Pub Date : 2023-04-03 , DOI: 10.1001/jamaneurol.2023.0455
Gillian T Coughlan ₁ , Tobey J Betthauser _{2,

3} , Rory Boyle ₁ , Rebecca L Koscik _{2,

3} , Hannah M Klinger ₁ , Lori B Chibnik _{1,

4} , Erin M Jonaitis _{2,

3} , Wai-Ying Wendy Yau ₁ , Allen Wenzel ₃ , Bradley T Christian ₂ , Carey E Gleason ₂ , Ursula G Saelzler ₅ , Michael J Properzi ₁ , Aaron P Schultz _{1,

6} , Bernard J Hanseeuw _{1,

6,

7,

8,

9} , JoAnn E Manson ₄ , Dorene M Rentz _{1,

6} , Keith A Johnson _{6,

8} , Reisa Sperling _{1,

6} , Sterling C Johnson _{2,

3} , Rachel F Buckley _{1,

6,

10}

Affiliation

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison.
Department of Medicine, University of Wisconsin-Madison, Madison.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Department of Psychiatry, University of California, San Diego, San Diego.
Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, Massachusetts.
Department of Neurology, Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Belgium.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.
Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.

Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels of tau in cognitively unimpaired postmenopausal females compared with age-matched males, particularly in the setting of high β-amyloid (Aβ). The biological mechanisms associated with higher tau deposition in female individuals remain elusive.

中文翻译：

更年期年龄与 Tau 和 β-淀粉样蛋白正电子发射断层扫描激素治疗的关系。

绝经后女性约占所有阿尔茨海默病患者的 70%。先前的文献显示，与年龄匹配的男性相比，认知未受损的绝经后女性的 tau 蛋白水平升高，尤其是在 β-淀粉样蛋白 (Aβ) 高的情况下。与女性个体中较高的 tau 沉积相关的生物学机制仍然难以捉摸。

更新日期：2023-04-03

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