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Chimeric transcripts of transposable elements and genes are a source of tumor-specific antigens
Nature Genetics ( IF 31.7 ) Pub Date : 2023-04-03 , DOI: 10.1038/s41588-023-01361-7
Nature Genetics ( IF 31.7 ) Pub Date : 2023-04-03 , DOI: 10.1038/s41588-023-01361-7
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Transposable elements (TEs) are transcriptionally activated in cancer and can generate chimeric TE–gene transcripts that are tumor specific. Our pan-cancer study reveals that these transcripts are a source of tumor-specific antigens that are shared across tumor types, bind to HLA and are presented on the extracellular surface of cancer cells appended to membrane-bound proteins.
更新日期：2023-04-03
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