A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry,Organic Process Research & Development

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A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2023-03-31 , DOI: 10.1021/acs.oprd.2c00291
Paridhi Agrawal ₁ , Katerina Wilkstein ₁ , Emily Guinn ₁ , McKensie Mason ₁ , Carolina I. Serrano Martinez ₁ , Jeremiah Saylae ₂

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Tangential flow filtration is an efficient membrane separation technology utilized across a wide range of industries for separation and purification applications. The requirement of telescoped manufacturing to produce high-volume drugs in the pharmaceutical industry has led to increased adoption of membrane separation for drug substance synthesis. Particularly, for noncrystalline molecules with limited product stability and significant thermal liabilities, TFF is a powerful alternative to traditional isolation techniques. This Review discusses the various considerations during the development of a TFF process and highlights applications of TFF to produce pharmaceutically relevant molecules such as proteins, peptides, monoclonal antibodies, and so on. Finally, a future perspective on the technology is shared for improved performance.

中文翻译：

切向流过滤综述：制药行业的工艺开发和应用

切向流过滤是一种高效的膜分离技术，在广泛的行业中用于分离和纯化应用。在制药行业中，对伸缩制造生产大批量药物的要求导致药物合成中越来越多地采用膜分离。特别是，对于产品稳定性有限和热负债显着的非晶分子，TFF 是传统分离技术的有力替代品。本综述讨论了 TFF 工艺开发过程中的各种注意事项，并重点介绍了 TFF 在生产蛋白质、肽、单克隆抗体等药物相关分子方面的应用。最后，分享了该技术的未来前景以提高性能。

更新日期：2023-03-31

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