Microneedles have demonstrated an essential role in transdermal drug delivery strategy. Attempts to advance this technology focus on the improvement of functionality to realize controllable drug release with a self-reporting capability. Here, we present multifunctional structural color triboelectric microneedle (MN) patches with the desired features for treating psoriasis. Such MN patches are made of a budesonide-encapsulated polyacrylamide-poly(ethylene glycol) diacrylate-lithium chloride (PAM-PEGDA-LiCl) ionic hydrogel, which possesses inverse opal scaffold structures. The resultant MN patches are not only forced to release drugs but also contribute to reducing the degree of skin fibrosis with their mechanical behavior, thereby promoting the treatment of psoriasis. Notably, these MN patches exhibit vivid structural color, imparting them with self-reporting capability, which can be applied for visually monitoring the performance of drug release during in vivo treatment of psoriasis mice. We believe that the proposed MN patches would be valuable in practical applications.

微针已在透皮给药策略中发挥重要作用。推进这项技术的尝试集中在功能的改进上，以实现具有自我报告能力的可控药物释放。在这里，我们展示了具有治疗牛皮癣所需功能的多功能结构色摩擦电微针 (MN) 贴片。这种 MN 贴片由布地奈德包裹的聚丙烯酰胺-聚（乙二醇）二丙烯酸酯-氯化锂 (PAM-PEGDA-LiCl) 离子水凝胶制成，具有反蛋白石支架结构。由此产生的 MN 贴片不仅被迫释放药物，而且还有助于通过其机械行为降低皮肤纤维化程度，从而促进银屑病的治疗。值得注意的是，这些 MN 斑块呈现出生动的结构色，牛皮癣小鼠的体内治疗。我们相信所提出的 MN 补丁在实际应用中将很有价值。