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Bioaccumulation, Trophic Transfer, and Biotransformation of Polychlorinated Diphenyl Ethers in a Simulated Aquatic Food Chain
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2023-03-28 , DOI: 10.1021/acs.est.2c08216
Xuesheng Zhang 1, 2 , Wenli Xiong 1, 2 , Qiuxuan Wu 3 , Kainan Nian 1, 2 , Xiaoxue Pan 1 , Doug Crump 4 , Xiaoxiang Wang 5 , Yishan Lin 6 , Xiaowei Zhang 7 , Rui Zhang 3
Affiliation  

Polychlorinated diphenyl ethers (PCDEs) are detected in aquatic environments and demonstrate adverse effects in aquatic organisms. However, data regarding the environmental behavior of PCDEs in aquatic ecosystems are lacking. In the present study, a simulated aquatic food chain (Scenedesmus obliquusDaphnia magnaDanio rerio) was constructed in a lab setting, and the bioaccumulation, trophic transfer, and biotransformation of 12 PCDE congeners were quantitatively investigated for the first time. The log-transformed bioaccumulation factors (BCFs) of PCDEs in S. obliquus, D. magna, and D. rerio were in the range of 2.94–3.77, 3.29–4.03, and 2.42–2.89 L/kg w.w., respectively, indicating the species-specific bioaccumulation of PCDE congeners. The BCF values increased significantly with the increasing number of substituted Cl atoms, with the exception of CDE 209. The number of Cl atoms at the para and meta positions were found to be the major positive contributing factors for BCFs in the case of the same number of substituted Cl. The lipid-normalized biomagnification factors (BMFs) of S. obliquus to D. magna, D. magna to D. rerio, and the whole food chain for the 12 PCDE congeners ranged at 1.08–2.27, 0.81–1.64, and 0.88–3.64, respectively, suggesting that some congeners had BMFs comparable to PBDEs and PCBs. Dechlorination was the only metabolic pathway observed for S. obliquus and D. magna. For D. rerio, dechlorination, methoxylation, and hydroxylation metabolic pathways were observed. 1H nuclear magnetic resonance (NMR) experiments and theoretical calculations confirmed that methoxylation and hydroxylation occurred at the ortho position of the benzene rings. In addition, reliable quantitative structure–property relationship (QSPR) models were constructed to qualitatively describe the relationships between molecular structure descriptors and BCFs for PCDEs. These findings provide insights into the movement and transformation of PCDEs in aquatic ecosystems.

中文翻译:

多氯联苯醚在模拟水生食物链中的生物积累、营养转移和生物转化

在水生环境中检测到多氯联苯醚 (PCDE),并对水生生物产生不利影响。然而,缺乏关于 PCDEs 在水生生态系统中的环境行为的数据。本研究在实验室环境中构建了模拟水生食物链(斜生栅藻-大型蚤-斑马鱼),首次对 12 种 PCDE 同系物的生物富集、营养转移和生物转化进行了定量研究。S. obliquusD. magnaD. rerio中 PCDE 的对数转换生物蓄积因子 (BCF)分别在 2.94-3.77、3.29-4.03 和 2.42-2.89 L/kg ww 的范围内,表明 PCDE 同系物的物种特异性生物累积。BCF 值随着取代的 Cl 原子数量的增加而显着增加,但 CDE 209 除外。在对位的 Cl 原子数量被发现是相同数量情况下 BCF 的主要积极贡献因素取代的Cl。S. obliquusD. magnaD. magnaD. rerio的脂质标准化生物放大因子 (BMF),而 12 种 PCDE 同系物的整个食物链范围分别为 1.08–2.27、0.81–1.64 和 0.88–3.64,表明某些同系物的 BMF 可与 PBDE 和 PCB 相媲美。脱氯作用是观察到的S. obliquusD. magna的唯一代谢途径。对于D. rerio,观察到脱氯、甲氧基化和羟基化代谢途径。1 H核磁共振(NMR)实验和理论计算证实甲氧基化和羟基化发生在邻位苯环的位置。此外,还构建了可靠的定量结构-性质关系 (QSPR) 模型来定性描述分子结构描述符与 PCDE 的 BCF 之间的关系。这些发现为了解 PCDE 在水生生态系统中的运动和转化提供了见解。
更新日期:2023-03-28
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