Using single-cell transcriptomics and functional assays, we identified various subsets of pancreatic beta cells. One subset, characterized by high levels of CD63, demonstrated enhanced glucose metabolism, mitochondrial activity, and glucose-induced insulin secretion, and the proportion of these beta cells was decreased in mouse models of type 2 diabetes (T2D) and humans with T2D.

中文翻译：

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2 型糖尿病发病机制中 β 细胞异质性的扰动

使用单细胞转录组学和功能测定，我们确定了胰腺 β 细胞的各种亚群。一个以高水平 CD63 为特征的亚群表现出增强的葡萄糖代谢、线粒体活性和葡萄糖诱导的胰岛素分泌，并且这些 β 细胞的比例在 2 型糖尿病 (T2D) 小鼠模型和患有 T2D 的人类中有所降低。