超声心动图联合血清C反应蛋白水平对慢性心力衰竭的诊断价值,Journal of Cardiothoracic Surgery

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超声心动图联合血清C反应蛋白水平对慢性心力衰竭的诊断价值
Journal of Cardiothoracic Surgery ( IF 1.5 ) Pub Date : 2023-03-25 , DOI: 10.1186/s13019-023-02176-7
Yongxia Zhang ₁

Affiliation

慢性心力衰竭(chronic heart failure, CHF)被认为是临床常见的心脏病。本研究旨在探讨超声心动图（Echo）和血清C反应蛋白（CRP）水平对CHF患者的临床诊断价值。共纳入 75 名 CHF 患者（42 名男性，33 名女性，年龄 62.72 ± 1.06 岁）作为研究对象，70 名非 CHF 患者（38 名男性，32 名女性，年龄 62.44 ± 1.28 岁）作为对照。Echo测定左心室射血分数（LVEF）、左心室缩短率（FS）和舒张早晚充盈（E/A），然后用ELISA检测血清CRP的表达。此外，采用Pearson方法分析超声心动图定量参数（EQPs）（LVEF、FS和E/A）与血清CRP水平的相关性。采用受试者工作特征（ROC）曲线评价EQPs和血清CRP水平对CHF的诊断效能。CHF患者的独立危险因素通过逻辑回归分析来衡量。CHF患者血清CRP水平升高，LVEF和FS值降低，E/A值升高。ROC曲线显示EQPs（LVEF、FS和E/A）联合血清CRP对CHF患者具有较高的诊断价值。Logistic回归分析显示EQPs（LVEF、FS和E/A）和血清CRP水平是CHF患者的独立危险因素。Echo联合血清CRP水平对CHF患者具有较高的临床诊断价值。CHF患者的独立危险因素通过逻辑回归分析来衡量。CHF患者血清CRP水平升高，LVEF和FS值降低，E/A值升高。ROC曲线显示EQPs（LVEF、FS和E/A）联合血清CRP对CHF患者具有较高的诊断价值。Logistic回归分析显示EQPs（LVEF、FS和E/A）和血清CRP水平是CHF患者的独立危险因素。Echo联合血清CRP水平对CHF患者具有较高的临床诊断价值。CHF患者的独立危险因素通过逻辑回归分析来衡量。CHF患者血清CRP水平升高，LVEF和FS值降低，E/A值升高。ROC曲线显示EQPs（LVEF、FS和E/A）联合血清CRP对CHF患者具有较高的诊断价值。Logistic回归分析显示EQPs（LVEF、FS和E/A）和血清CRP水平是CHF患者的独立危险因素。Echo联合血清CRP水平对CHF患者具有较高的临床诊断价值。Logistic回归分析显示EQPs（LVEF、FS和E/A）和血清CRP水平是CHF患者的独立危险因素。Echo联合血清CRP水平对CHF患者具有较高的临床诊断价值。Logistic回归分析显示EQPs（LVEF、FS和E/A）和血清CRP水平是CHF患者的独立危险因素。Echo联合血清CRP水平对CHF患者具有较高的临床诊断价值。

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Diagnostic value of echocardiography combined with serum C-reactive protein level in chronic heart failure

Chronic heart failure (CHF) is regarded as common clinical heart disease. This study aims to investigate the clinical diagnostic value of echocardiography (Echo) and serum C-reactive protein (CRP) levels in patients with CHF. A total of 75 patients with CHF (42 males, 33 females, age 62.72 ± 1.06 years) were enrolled as study subjects, with 70 non-CHF subjects (38 males, 32 females, age 62.44 ± 1.28 years) as controls. The left ventricular ejection fraction (LVEF), fraction shortening rate of the left ventricle (FS), and early to late diastolic filling (E/A) were determined by Echo, followed by an examination of the expression of serum CRP by ELISA. In addition, the Pearson method was used to analyze the correlation between echocardiographic quantitative parameters (EQPs) (LVEF, FS, and E/A) and serum CRP levels. Receiver operating characteristic (ROC) curve was adopted to evaluate the diagnostic efficacy of EQPs and serum CRP levels for CHF. The independent risk factors for CHF patients were measured by logistics regression analysis. The serum CRP level of CHF patients was elevated, the values of LVEF and FS decreased, and the E/A values increased. ROC curve revealed that the EQPs (LVEF, FS, and E/A) combined with serum CRP had high diagnostic values for CHF patients. Logistic regression analysis showed that the EQPs (LVEF, FS, and E/A) and serum CRP levels were independent risk factors for CHF patients. Echo combined with serum CRP level has high clinical diagnostic values for CHF patients.

更新日期：2023-03-26

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