The treatment of acne vulgaris and enlarged pore remains challenging. The 30% supramolecular salicylic acid (SSA) is a newly developed form of SA which affects pathogenic factors of acne. Non-ablative fractional laser (NAFL) promotes remodeling and decreases sebum excretion with minimal side effect. The current study was aimed to evaluate the sequential modality with 30% SSA followed by 1565-nm NAFL on facial acne and subsequent enlarged pores. A 20-week-duration prospective study was performed. Consecutive 4 sessions of 30% SSA treatment were conducted, at 2-week intervals. Two weeks after the last session of 30% SSA, 3 sessions of 1565-nm NAFL treatment were applied, at 4-week intervals. The noninvasive devices measured scores of red areas and pores, cuticle moisture, and sebum secretion. The main subjective evaluation was global acne grading system (GAGS). The side effects were recorded. Compared to baseline, the scores of red areas and pores, sebum secretion, and GAGS significantly decreased after series sessions of 30% SSA treatments (P < 0.05). The sequential application of 1565-nm NAFL maintained the good results (P < 0.05, comparing to baseline) and even further decreased the sebum secretion (P < 0.05, comparing to SSA). The cuticle moisture remained unchanged during whole period, and side effects including tingling sensation, pain, erythema, and edema were quickly reversible and acceptable. The significant improvements of acne and pores were produced by 30% SSA, and 1565-nm NAFL inhibited the sebum secretion and maintained the efficacies of 30% SSA. The sequential modality of 30% SSA followed by 1565-nm NAFL was an alternative choice for acne vulgaris companied with enlarged pores.

寻常痤疮和毛孔粗大的治疗仍然具有挑战性。30% 超分子水杨酸 (SSA) 是一种新开发的 SA，可影响痤疮的致病因素。非烧蚀性点阵激光 (NAFL) 可促进重塑并减少皮脂排泄，且副作用最小。目前的研究旨在评估 30% SSA 随后 1565 nm NAFL 对面部痤疮和随后毛孔粗大的连续模式。进行了为期 20 周的前瞻性研究。以 2 周的间隔进行连续 4 次 30% SSA 治疗。在最后一次 30% SSA 治疗两周后，每隔 4 周进行 3 次 1565 nm NAFL 治疗。非侵入性设备测量了红色区域和毛孔、角质层水分和皮脂分泌的分数。主要的主观评价是全球痤疮分级系统（GAGS）。记录副作用。与基线相比，在 30% SSA 治疗系列后，红色区域和毛孔、皮脂分泌和 GAGS 的评分显着降低（P  < 0.05）。顺序应用 1565 nm NAFL 保持了良好的结果（与基线相比P  < 0.05），甚至进一步降低了皮脂分泌（ 与 SSA 相比P < 0.05）。整个期间角质层水分保持不变，刺痛、疼痛、红斑和水肿等副作用很快可逆并可以接受。30% SSA对粉刺和毛孔有明显改善，1565-nm NAFL抑制皮脂分泌，保持30% SSA的功效。30% SSA 后接 1565 nm NAFL 的序贯模式是伴有毛孔粗大的寻常痤疮的另一种选择。