Zhong, Xin, Wenqiong Du, Zhaowen Zong, Renqing Jiang, Yijun Jia, Zhao Ye, and Haoyang Yang. Features of coagulo-fibrinolytic derangement due to bleeding in nonacclimatized rabbits acutely exposed to high altitude. High Alt Med Biol. 24:68-75, 2023. Background: The present study aimed to observe the time course of coagulo-fibrinolytic derangement due to bleeding in rabbits acutely exposed to high altitude (HA). Materials and Methods: Forty-eight rabbits were randomly divided into four groups and were subjected to minor bleeding at low altitude, major bleeding at low altitude, minor bleeding after acute exposure to HA, and major bleeding after acute exposure to HA. To produce minor and major bleeding, 10% and 30% of the total blood volume was removed, respectively. At designated time points, samples were taken for laboratory examination. Results: While minor bleeding at low altitude led to minor coagulo-fibrinolytic derangements, it led to complicated derangements at HA, which presented as an early hypercoagulable state and transition to hypocoagulable and hyperfibrinolytic states with lower clot firmness. Major bleeding at HA resulted in greater derangements of the R time, K values, the D-dimer concentration, the alpha angle, maximum amplitude, and the concentration of fibrinogen than were observed at low altitude. Conclusions: The extent of coagulo-fibrinolytic derangements due to bleeding in rabbits after acute exposure to HA was more severe and complicated than that at low altitude. Therefore, proper resuscitation should be applied based on these changes.

中文翻译：

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急性暴露于高海拔的未适应环境的兔出血引起的凝血纤维蛋白溶解紊乱的特征。

钟、鑫、杜文琼、宗兆文、蒋仁庆、贾宜君、叶兆和杨浩阳。非驯化兔急性高原出血致凝血纤溶紊乱的特点。高 Alt 医学生物学。24:68-75, 2023. 背景：本研究旨在观察急性暴露于高海拔 (HA) 的兔因出血导致的凝血纤维蛋白溶解紊乱的时间进程。材料与方法：48只家兔随机分为4组，分为低海拔小出血组、低海拔大出血组、急性接触HA后小出血组、急性接触HA后大出血组。为了产生小出血和大出血，分别去除了总血量的 10% 和 30%。在指定的时间点，取样进行实验室检查。结果：虽然低海拔地区的轻微出血会导致轻微的凝血纤维蛋白溶解紊乱，但它会导致 HA 出现复杂的紊乱，表现为早期的高凝状态并转变为低凝和高纤溶状态，凝块硬度较低。HA 的大出血导致 R 时间、K 值、D-二聚体浓度、α 角、最大幅度和纤维蛋白原浓度的紊乱比在低海拔观察到的更大。结论：家兔急性暴露于HA后出血引起的凝血纤溶紊乱程度较低海拔更严重、更复杂。因此，应根据这些变化进行适当的复苏。其表现为早期高凝状态并转变为低凝和高纤溶状态，凝块硬度较低。HA 的大出血导致 R 时间、K 值、D-二聚体浓度、α 角、最大幅度和纤维蛋白原浓度的紊乱比在低海拔观察到的更大。结论：家兔急性暴露于HA后出血引起的凝血纤溶紊乱程度较低海拔更严重、更复杂。因此，应根据这些变化进行适当的复苏。其表现为早期高凝状态并转变为低凝和高纤溶状态，凝块硬度较低。HA 的大出血导致 R 时间、K 值、D-二聚体浓度、α 角、最大幅度和纤维蛋白原浓度的紊乱比在低海拔观察到的更大。结论：家兔急性暴露于HA后出血引起的凝血纤溶紊乱程度较低海拔更严重、更复杂。因此，应根据这些变化进行适当的复苏。最大幅度和纤维蛋白原的浓度比在低海拔处观察到的要高。结论：家兔急性暴露于HA后出血引起的凝血纤溶紊乱程度较低海拔更严重、更复杂。因此，应根据这些变化进行适当的复苏。最大幅度和纤维蛋白原的浓度比在低海拔处观察到的要高。结论：家兔急性暴露于HA后出血引起的凝血纤溶紊乱程度较低海拔更严重、更复杂。因此，应根据这些变化进行适当的复苏。