ABSTRACT

To investigate the changes of serum neuron-specific enolase (NSE), lactate and C-reactive protein (CRP) in patients with postoperative infection after acute craniocerebral injury and their predictive value for prognosis. 71 patients with postoperative infection after acute craniocerebral injury were selected as infection group, and 56 patients without postoperative infection were selected as non-infection group. NSE, CRP and blood lactic acid levels were detected in all patients. The relationship between each index and thecondition and prognosis of patients was analyzed. The levels of serum NSE, lactic acid and CRP in infected group were higher than those in non-infection group (P<0.05). The levels of serum NSE, lactic acid and CRP in severe group were higher than those in mild group (P<0.05). Serum levels of NSE, lactic acid and CRP were positively correlated with the severity of infection (P<0.05), the area under the curve (AUC) of the receiver operating characteristic curve (ROC) was greater than that of the NSE level (P<0.05). The levels of serum NSE, lactate and CRP in the good prognosis group were lower than those in the poor prognosis group (P<0.05). The area under the curve (AUC) of receiver operating characteristic curve (ROC) of lactate level in predicting the prognosis of patients with infection was higher than that of NSE and CRP (P<0.05). Serum NSE, lactic acid and CRP have predictive value in patients with acute craniocerebral injury.

 抽象的

探讨急性颅脑损伤术后感染患者血清神经元特异性烯醇化酶（NSE）、乳酸和C反应蛋白（CRP）的变化及其对预后的预​​测价值。选择急性颅脑损伤术后发生感染的患者71例作为感染组，术后未发生感染的患者56例作为非感染组。所有患者均检测NSE、CRP和血乳酸水平。分析各指标与患者病情及预后的关系。感染组血清NSE、乳酸、CRP水平均高于非感染组(P<0.05)。重症组血清NSE、乳酸、CRP水平高于轻度组(P<0.05)。血清NSE、乳酸、CRP水平与感染严重程度呈正相关（P<0.05），受试者工作特征曲线（ROC）曲线下面积（AUC）大于NSE水平(P<0.05)。预后良好组血清NSE、乳酸、CRP水平均低于预后不良组(P<0.05)。乳酸水平预测感染患者预后的受试者工作特征曲线（ROC）曲线下面积（AUC）高于NSE和CRP（P<0.05）。血清NSE、乳酸、CRP对急性颅脑损伤患者有预测价值。