Soil erosion is a common form of land degradation. The Coupled Model Intercomparison Project Phase 6 (CMIP6) provides a scenario framework for global socio-economic development and climate change by combining Shared Socioeconomic Pathways (SSP) and Representative Concentration Pathways (RCP). The soil erosion estimation under global climate change and land-use change scenarios provided by CMIP6 is valuable for representing future changes and hotspots. This study estimated the future changes in soil erosion in the Three Gorges Reservoir (TGR) area, China, which has suffered severe soil loss over an extended period, and vegetation restoration projects have been conducted since 1999. The scenarios provided by SSP1-2.6, SSP2-4.5, and SSP5-8.5 were coupled with the scenarios of regional vegetation restoration projects to reflect future land use changes (LUC) and climate change. The results showed that future soil erosion from 2020 to 2100 in the TGR area will experience a non-significant decreasing trend (with trend slopes of −0.013, −0.020, and-0.006 in SSP1-2.6, SSP2-4.5, and SSP5-8.5, respectively, with p > 0.05). However, with the R factors calculated by different methods, this decreasing trend becomes either insignificant or a significant increasing trend. SSP1-2.6 will experience the lowest soil erosion in 2100 owing to the large amount of forest increase in this scenario. Furthermore, as estimates, the grain-for-green policy (GGP) will reduce 89353.47, 92737.73 and 42916.52 ton soil erosion per year in SSP1-2.6, SSP2-4.5 and SSP3-8.5 by 2100, respectively. In the future, the GGP will become increasingly important for controlling soil loss in the TGR area owing to the increasing precipitation in all scenarios, which increases the risk of soil loss.