Tire wear compounds N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its derivative 6PPD-quinone have been considered as emerging pollutants and attracted much attention recently. As an antioxidant and antiozonant widely used, 6PPD would be released during the production or use of rubber-related products. Because of the mass production and wide use of rubber-related products, 6PPD and 6PPD-quinone have been identified to be ubiquitous in the environment. In this study, we firstly reviewed the current available literature on the analytical procedures, concentrations and distribution of 6PPD and 6PPD-quinone, and then investigated the potential toxic effects of these two compounds on aquatic organisms. Current studies have been mainly focused on the occurrence of 6PPD and 6PPD-quinone in dust and water, while available information on atmosphere, soil, sediments and organisms is limited. The fate and distribution of 6PPD and 6PPD-quinone would be influenced by environmental factors such as temperature, illumination, and storm events, etc. Although 6PPD and 6PPD-quinone have potential adverse effects on aquatic organisms, and 6PPD-quinone has species-specific toxicity, toxicological mechanisms of these compounds are still unclear. Based on the review and analysis of current studies, some suggestions for future research of 6PPD and 6PPD-quinone are given.

轮胎磨损化合物N -(1,3-二甲基丁基)- N' -苯基- p-苯二胺（6PPD）及其衍生物6PPD-醌被认为是新兴污染物，近年来备受关注。6PPD作为一种应用广泛的抗氧剂和抗臭氧剂，在橡胶相关产品的生产或使用过程中会释放出来。由于橡胶相关产品的大量生产和广泛使用，6PPD 和 6PPD-醌已被确定在环境中无处不在。在这项研究中，我们首先回顾了目前有关 6PPD 和 6PPD-醌的分析程序、浓度和分布的现有文献，然后研究了这两种化合物对水生生物的潜在毒性作用。目前的研究主要集中在尘埃和水中6PPD和6PPD-醌的发生，而关于大气、土壤、沉积物和生物的可用信息有限。6PPD和6PPD-醌的归宿和分布受温度、光照、风暴事件等环境因素的影响。虽然6PPD和6PPD-醌对水生生物有潜在的不利影响，6PPD-醌具有物种特异性毒性，这些化合物的毒理机制尚不清楚。在对现有研究进行回顾和分析的基础上，对6PPD和6PPD-醌的未来研究提出了一些建议。