Acanthopanax senticosus (Rupr. Maxim.; AS) is a medicinal plant used in the clinical treatment of cerebrovascular diseases and central nervous system disorders, and it significantly improves blood lipid levels and endothelial cell function in patients with acute cerebral infarction. Isofraxidin, one of the active ingredients of AS, is the core of the plant’s medical effects, and its extraction depends on organic solvents. Deep eutectic solvents (DESs) are new green solvents synthesized by intermolecular hydrogen bonding between hydrogen bond donors (HBD) and hydrogen bond acceptors (HBA) which are non-toxic, have a high separation and extraction efficiency, and are environmentally friendly compared to traditional organic solvents. In this paper, DES was used for the extraction of isofraxidin from AS. The primary findings demonstrated that the DES had a viscosity higher than that of ethanol, and even adding a small amount of water (approximately 10%) would trigger solvent redistribution, leading to a considerable reduction in solvent viscosity. In comparison to ethanol, the extraction rate of isofraxidin by DES was 2–3 times higher. Thus, this work developed a new technique for using green extraction of isofraxidin that has some practical implications.

中文翻译：

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氯化胆碱和柠檬酸合成的低共熔溶剂绿色分离提取刺五加中的异秦皮苷

Acanthopanax senticosus (Rupr. Maxim.; AS) 是一种用于临床治疗脑血管疾病和中枢神经系统疾病的药用植物，可显着改善急性脑梗死患者的血脂水平和内皮细胞功能。Isofraxidin是AS的有效成分之一，是植物药效的核心，其提取依赖于有机溶剂。低共熔溶剂（DESs）是通过氢键供体（HBD）和氢键受体（HBA）之间的分子间氢键作用合成的新型绿色溶剂，与传统溶剂相比无毒、分离萃取效率高、环境友好。有机溶剂。在本文中，DES 用于从 AS 中提取异秦皮素。主要研究结果表明，DES 的粘度高于乙醇，即使添加少量水（约 10%）也会引发溶剂重新分布，从而导致溶剂粘度显着降低。与乙醇相比，DES 对 isofraxidin 的提取率高 2-3 倍。因此，这项工作开发了一种使用绿色提取 isofraxidin 的新技术，具有一定的实际意义。