Effective screening and treatment have reduced the number of women dying from breast cancer (BC). However, the long-term sequelae of BC treatment and psychosocial factors seriously affect the life quality of BC patients and survivors. Therefore, the discovery and application of targeted biomarkers to improve the functional outcome and life quality of BC patients is necessary. To explore the impact of leptin (LEP)/ leptin receptor (LEPR) expression on occurrence and survival of BC. Totally 132 primary BC and 66 non-BC patients who underwent surgery in department of breast surgery in Shanxi Cancer Hospital from January to October in 2009 were enrolled in this retrospective study. LEP and LEPR were examined in BC tissues, benign breast tissues, para-carcinoma tissues using immunohistochemical staining. Kaplan–Meier curve was generated to test survival time. The high level expression of LEP and LEPR in BC tissues were significantly higher than that in benign breast tissues and in para-carcinoma tissues (all P < 0.05). The LEP expression in patients with lymph node metastases was significantly higher than that in patients without lymph nodes metastases (P = 0.002). LEPR expression was correlated with higher Ki-67 rate (P = 0.002). LEP and LEPR both had no impact on survival (all P > 0.05). High LEP/LEPR expression were risk factors for occurrence of BC, but without impact on survival.

中文翻译：

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瘦素和瘦素受体表达作为乳腺癌的生物标志物：一项回顾性研究

有效的筛查和治疗减少了死于乳腺癌 (BC) 的女性人数。然而，BC治疗的长期后遗症和心理社会因素严重影响BC患者和幸存者的生活质量。因此，有必要发现和应用靶向生物标志物以改善 BC 患者的功能结果和生活质量。探讨瘦素（LEP）/瘦素受体（LEPR）表达对BC发生和存活的影响。回顾性研究2009年1-10月在山西省肿瘤医院乳腺外科接受手术的132例原发性BC患者和66例非BC患者。使用免疫组织化学染色在 BC 组织、良性乳腺组织、癌旁组织中检查 LEP 和 LEPR。生成 Kaplan-Meier 曲线以测试生存时间。LEP和LEPR在BC组织中的高表达显着高于良性乳腺组织和癌旁组织（均P < 0.05）。有淋巴结转移患者的LEP表达明显高于无淋巴结转移患者（P=0.002）。LEPR 表达与较高的 Ki-67 率相关 (P = 0.002)。LEP 和 LEPR 均对生存没有影响（均 P > 0.05）。LEP/LEPR高表达是BC发生的危险因素，但对生存无影响。有淋巴结转移患者的LEP表达明显高于无淋巴结转移患者（P=0.002）。LEPR 表达与较高的 Ki-67 率相关 (P = 0.002)。LEP 和 LEPR 均对生存没有影响（均 P > 0.05）。LEP/LEPR高表达是BC发生的危险因素，但对生存无影响。有淋巴结转移患者的LEP表达明显高于无淋巴结转移患者（P=0.002）。LEPR 表达与较高的 Ki-67 率相关 (P = 0.002)。LEP 和 LEPR 均对生存没有影响（均 P > 0.05）。LEP/LEPR高表达是BC发生的危险因素，但对生存无影响。