Polymorphisms of placental iodothyronine deiodinase genes in a rural area of Northern China with high prevalence of neural tube defects,Human Heredity

当前位置： X-MOL 学术 › Hum. Hered. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Polymorphisms of placental iodothyronine deiodinase genes in a rural area of Northern China with high prevalence of neural tube defects
Human Heredity ( IF 1.1 ) Pub Date : 2023-03-21 , DOI: 10.1159/000530112
Fang Wang ₁ , Yan-Hong Gu _{2,

3} , Jin Guo ₄ , YiHua Bao ₄ , ZhiYong Qiu ₄ , Ping Zheng ₅ , Masaru Ushijima ₆ , Masaaki Matsuura ₇ , Ting Zhang ₄

Affiliation

Introduction: We have reported that high total homocysteine (tHCY), and the coexistence of inadequate thyroid hormones in maternal serum increase the risk of fetal neural tube defects (NTDs). Placental iodothyronine deiodinases (DIOs: DIO1, DIO2, and DIO3) play a role in regulate the conversions between different forms of maternal thyroid hormones. This study hypothesized that single nucleotide polymorphisms (SNPs) in placental DIOs genes could be related to NTDs. Methods: We performed a case-control study from 2007 to 2009 that included pregnant women from Lüliang, Shanxi Province, China. Nine distinct SNPs in DIOs genes were analyzed and placental samples were obtained from 83 pregnant women with NTDs fetuses and 90 pregnant women with normal fetuses. The nine SNPs were analyzed using the Cochran–Armitage test and the Fisher’s exact test. Results: There were no statistically significant differences between case and control in the nine SNPs of DIOs (P>0.05). Conclusions: The results of this study suggested that SNPs of DIOs genes in placenta among pregnant women has no statistically significant difference between the two groups, suggesting that other factors might be involved in metabolism of maternal thyroid hormone provided to fetuses, such as epigenetic modification of methylation and homocysteinylation and genomic imprinting in the placenta. Further those functional studies on placenta samples are necessary.

更新日期：2023-03-21

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11