Advanced and Readily-Available Wireless-Powered Blue-Light-Implant for Non-Invasive Peri-Implant Disinfection,Advanced Science

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Advanced and Readily-Available Wireless-Powered Blue-Light-Implant for Non-Invasive Peri-Implant Disinfection
Advanced Science ( IF 14.3 ) Pub Date : 2023-03-19 , DOI: 10.1002/advs.202203472
Ludan Zhang ₁ , Yamin Li _{2,

3} , Lintian Yuan ₁ , Qianyi Zhang ₄ , Yuqing Yan ₅ , Fan Dong ₁ , Jun Tang _{2,

3} , Yuguang Wang ₁

Affiliation

Non-invasive light-based antibacterial therapy has a good prospect in non-surgical treatment of peri-implant infections. However, its applications are severely limited by poor penetration of light into human tissues, leading to unsatisfying outcomes. Moreover, as an essential prerequisite for traditional light therapy, lasers can no longer meet the patients’ needs for convenient treatment at any time. To break through the spatial and temporal limitations of traditional light therapy, a wireless-powered blue-light zirconia implant for readily available treatment of peri-implant infection is proposed. In space, complete irradiation to complex peri-implant structure is realized by the built-in wireless-powered light source, thus improving the efficacy. In time, wireless-powering allows timely and controllable anti-infection treatment. Blue micro-light emitting diodes are used as therapeutic light sources, which effectively kill peri-implant infection-related bacteria without exogenous photosensitive agents. Porphyromonas gingivalis biofilm on implant surface can be completely killed after 20 min irradiation in vitro. The bactericidal rate of peri-implant methicillin-resistant Staphylococcus aureus infection reaches 99.96 ± 0.03% under 30 min per day blue light exposure in vivo. Within the scope of this study, the treatment of peri-implant infection with blue-light implant has preliminary feasibility, giving a new approach to non-invasive treatment of deep oral infections, including peri-implant infections.

中文翻译：

用于非侵入性种植体周围消毒的先进且现成的无线供电蓝光植入体

基于光的无创抗菌疗法在种植体周围感染的非手术治疗中具有良好的前景。然而，由于光对人体组织的穿透力差，其应用受到严重限制，导致结果不尽如人意。而且，激光作为传统光疗必不可少的先决条件，已经不能满足患者随时方便治疗的需求。为了突破传统光疗法的空间和时间限制，提出了一种无线供电的蓝光氧化锆植入物，用于治疗植入物周围感染。在太空中，通过内置的无线供电光源实现对复杂种植体周围结构的完整照射，从而提高疗效。随着时间的推移，无线供电允许及时和可控的抗感染治疗。种植体表面的牙龈卟啉单胞菌生物膜在体外照射20分钟后即可被完全杀死。体内每天30分钟蓝光照射对种植体周围耐甲氧西林金黄色葡萄球菌感染的杀菌率达到99.96±0.03%。在本研究范围内，蓝光种植体治疗种植体周围感染具有初步可行性，为口腔深部感染包括种植体周围感染的无创治疗提供了一种新途径。

更新日期：2023-03-19

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