Supportive Care in Cancer ( IF 2.8 ) Pub Date : 2023-03-20 , DOI: 10.1007/s00520-023-07686-7 Siyuan Hao 1 , Yixin Jin 1 , Yue Yu 1 , Jiantao Wang 2 , Jing Zou 1 , Yan Wang 1
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Background
Radiotherapy-induced oral mucositis (RIOM) and chemotherapy-induced oral mucositis (CIOM) are common complications in cancer patients, leading to negative clinical manifestations, reduced quality of life, and unsatisfactory treatment outcomes.
Objective
The present study aimed to identify potential molecular mechanisms and candidate drugs by data mining.
Methods
We obtained a preliminary list of genes associated with RIOM and CIOM. In-depth information on these genes was explored by functional and enrichment analyses. Then, the drug–gene interaction database was used to determine the interaction of the final enriched gene list with known drugs and analyze the drug candidates.
Results and conclusion
This study identified 21 hub genes that may play an important role in RIOM and CIOM, respectively. Through our data mining, bioinformatics survey, and candidate drug selection, TNF, IL-6, and TLR9 could play an important role in disease progression and treatment. In addition, eight candidate drugs (olokizumab, chloroquine, hydroxychloroquine, adalimumab, etanercept, golimumab, infliximab, and thalidomide) were selected by the drug–gene interaction literature search additionally, as candidates for treating RIOM and CIOM.
中文翻译：
鉴定放疗和化疗引起的粘膜炎的潜在分子机制和候选药物
背景
放疗引起的口腔粘膜炎 (RIOM) 和化疗引起的口腔粘膜炎 (CIOM) 是癌症患者的常见并发症，可导致不良临床表现、生活质量下降和治疗效果不理想。
客观的
本研究旨在通过数据挖掘确定潜在的分子机制和候选药物。
方法
我们获得了与 RIOM 和 CIOM 相关的基因的初步列表。通过功能和富集分析探索了有关这些基因的深入信息。然后，利用药物-基因相互作用数据库确定最终富集的基因列表与已知药物的相互作用，并对候选药物进行分析。
结果和结论
本研究确定了 21 个可能分别在 RIOM 和 CIOM 中发挥重要作用的中枢基因。通过我们的数据挖掘、生物信息学调查和候选药物选择，TNF、IL-6 和 TLR9 可能在疾病进展和治疗中发挥重要作用。此外，通过药物-基因相互作用文献检索，另外选择了8个候选药物（奥洛珠单抗、氯喹、羟氯喹、阿达木单抗、依那西普、戈利木单抗、英夫利昔单抗和沙利度胺）作为治疗RIOM和CIOM的候选药物。
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